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Description
GADD34 Recombinant Rabbit mAb (S-2267-246)Product Specification Host Rabbit Antigen GADD34 Synonyms Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog; PPP1R15A Immunogen Synthetic Peptide Location Mitochondrion, Endoplasmic reticulum Accession O75807 Clone Number S 2267 246 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Mk Positive Sample HepG2, Jurkat,
Product Specification
| Host | Rabbit |
| Antigen | GADD34 |
| Synonyms | Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog; PPP1R15A |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion, Endoplasmic reticulum |
| Accession | O75807 |
| Clone Number | S-2267-246 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Mk |
| Positive Sample | HepG2, Jurkat, K562, PC-3, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
Background
GADD34, also known as PPP1R15A, is a stress-inducible regulatory subunit of protein phosphatase 1 (PP1) that plays a crucial role in cellular stress responses by forming a complex with PP1 to dephosphorylate eIF2α, thereby promoting translational recovery during the integrated stress response (ISR), and is involved in various cellular processes including apoptosis, cell cycle arrest, and DNA damage response, with its expression being upregulated by a variety of stress signals such as DNA damage, endoplasmic reticulum (ER) stress, and oxidative stress, and has been implicated in several pathological conditions including cancer, neurodegenerative diseases, and metabolic disorders.
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