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Description
Human IFN-β Recombinant Rabbit mAb (S-3648)Product Specification Host Rabbit Antigen IFN Clone Number S 3648 Antibody Type Recombinant mAb Isotype IgG Application ELISA Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species ELISA 1: 5000 1: 10000 Hu
Product Specification
| Host | Rabbit |
| Antigen | IFN-β |
| Clone Number | S-3648 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Hu |
Background
Human Interferon Beta (IFNβ) is a naturally occurring cytokine belonging to the type I interferon family, primarily produced by fibroblasts and immune cells in response to viral infections or other inflammatory stimuli. It plays a critical role in the innate immune response by binding to the IFNα/β receptor (IFNAR), activating the JAK-STAT signaling pathway, and inducing the expression of interferon-stimulated genes (ISGs). These genes exert broad antiviral, immunomodulatory, and antiproliferative effects. IFNβ has been widely utilized as a therapeutic agent, particularly in the treatment of relapsing-remitting multiple sclerosis (MS), where it helps reduce inflammation and modulate immune activity. Recombinant forms of IFNβ (e.g., IFNβ-1a and IFNβ-1b) are clinically approved and demonstrate efficacy in decreasing relapse rates and slowing disease progression. Key functions of IFNβ include: Antiviral Activity: Enhances cellular resistance to viral infections. Immunoregulation: Suppresses pro-inflammatory cytokines (e.g., TNFα, IL-12) and promotes anti-inflammatory responses. Antiproliferative Effects: Inhibits the growth of certain tumor cells.
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