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Description
Caspase-1 Recombinant Rabbit mAb (S-2677-22)Product Specification Host Rabbit Antigen Caspase 1 Synonyms CASP 1; Interleukin 1 beta convertase (IL 1BC); Interleukin 1 beta converting enzyme (ICE; IL 1 beta converting enzyme); p45; Il1bc; Casp1 Immunogen Synthetic Peptide Location Cytoplasm Accession P29452 Clone Number S 2677 22 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms Positive Sample EL4, J774A. 1, A20 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Caspase-1 |
| Synonyms | CASP-1; Interleukin-1 beta convertase (IL-1BC); Interleukin-1 beta-converting enzyme (ICE; IL-1 beta-converting enzyme); p45; Il1bc; Casp1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P29452 |
| Clone Number | S-2677-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms |
| Positive Sample | EL4, J774A.1, A20 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:250 | Ms |
Background
Caspase-1, the canonical member of the inflammatory caspase subfamily, is synthesized as a 45 kDa zymogen that assembles into the ~700 kDa inflammasome platform via homotypic CARD–CARD interactions with ASC and NLRP proteins; proximity-induced dimerization and trans-autoproteolysis generate the active p20/p10 tetramer whose p10 subunit forms a heterodimeric active site that cleaves the tetrapeptide motifs WEHD and YVAD, liberating the pro-inflammatory cytokines IL-1β and IL-18, triggering pyroptosis through gasdermin-D pore formation, and thereby orchestrating innate immune defense, metabolic regulation, and, when dysregulated, autoinflammatory diseases such as CAPS, atherosclerosis, and Alzheimer’s pathology.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
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