SKU: 2894001396

Invivo anti-Mouse CD223 Recombinant mAb

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Description

Invivo anti-Mouse CD223 Recombinant mAbProduct Specification Host Rat Antigen CD223 Synonyms Lymphocyte activation gene 3 protein; LAG 3; Activation induced cytidine deaminase linked autoimmunity protein (Aida); Lag3 Location Secreted, Cell membrane Accession Q61790 Clone Number S R624 Antibody Type Rat mAb Isotype Rat IgG1,k Application FCM Reactivity Ms Positive Sample Mouse CD3, CD28 antibody treated C57BL 6 mouse splenocytes Purification Protein G Concentration 5 mg ml Purity >95%

Product Specification


Host Rat
Antigen CD223
Synonyms Lymphocyte activation gene 3 protein; LAG-3; Activation-induced cytidine deaminase-linked autoimmunity protein (Aida); Lag3
Location Secreted, Cell membrane
Accession Q61790
Clone Number S-R624
Antibody Type Rat mAb
Isotype Rat IgG1,k
Application FCM
Reactivity Ms
Positive Sample Mouse CD3, CD28 antibody treated C57BL/6 mouse splenocytes
Purification Protein G
Concentration 5 mg/ml
Purity >95% (Determined by SDS-PAGE)
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative
Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Dilution


application dilution species
FCM 1:500 Ms

Background

CD223, also known as LAG-3 (lymphocyte activation gene-3), is a type I transmembrane protein belonging to the immunoglobulin (Ig) superfamily. It is expressed on the surface of activated T cells, regulatory T cells (Tregs), natural killer (NK) cells, and some other immune cells. Structurally, it is similar to CD4 and has a higher binding affinity to MHC class II molecules than CD4. LAG-3 primarily functions as an immune checkpoint receptor, negatively regulating T-cell activation, proliferation, and cytokine production. In cancer and chronic infections, elevated LAG-3 expression is associated with T cell exhaustion, limiting anti-tumor and antiviral responses. Due to its significant role in immune regulation, LAG-3 has become a promising target for cancer immunotherapy and the treatment of autoimmune disorders.

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Exchange/Return Notes
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SKU: 2894001396

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4.2 ★★★★★
Based on 13 reviews
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J
Verified Purchase
Jan Wis
Fort Morgan, US
★★★★★ 5
EXCELLENT CHOICE
Color: Phoenix at a Bloody Mary Bar V1
My third pair! Fit is amazing! Lightweight, lots of colors to choose from and great sun protection!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 1, 2026
J
Verified Purchase
JS
Los Angeles, US
★★★★★ 5
Comfy, nonslip with nice lenses!
Color: Iced By Yetis V2
I have several pairs of Goodr glasses, and so I picked up yet another pair in this nice color combo of white and blue reflective lenses. The order said "v2", but I couldn't find much difference. I think there is an upgrade on the material or hinge? I guess it might feel a little more comfy on my face, but I had chalked that up to just being a new pair and not my old worn down pair that I wear daily. The size of the mediums (OG) is perfect for the average size face. You can even "try on" the glasses on the Goodr website if you aren't sure, but the measurements are a pretty good indicator if you need the regulars or need to change size. Goodr lenses are quality, and have great sun protection, especially with their reflective lenses. The only Goodrs I haven't liked too much are the more "clear" lenses where you can see your eyes clearly through the lenses from the front, but that is just a preference choice, and they have so many options. I'll probably look at picking up another color combo soon. I have about 5 pairs of the "OG" glasses, and they have all been great and super durable. The only thing I have noticed is the frames pickup a lot of grease from my face, especially if I wear sunblock, but I just wipe them down before and after use, and they seem to last forever. I also really like the little carrying case they give you, it doubles as a microfiber cloth. If you want more protection, the box it ships in is a sturdy little cardboard slider box that works very well for protection and storage.
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Reviewed in the United States on May 6, 2026
L
Verified Purchase
Landon Ellis
Birmingham, US
★★★★★ 4
High quality frames with weak polarization
I really like the look and feel of these glasses—they seem to be high quality. I like the fit and the non-slip texture of the frames. Two things detract from otherwise being exactly what I was looking for. First, and most importantly, the polarization seems less strong than what I’ve had in other sunglasses. Glare from shiny things like glass on cars and glare on my phone screen seems barely reduced compared to looking without the glasses (tilting my head makes barely any difference in the polarization). I’ve noticed that especially while driving. So I’m taking off one star for that. Another thing that is more just a personal preference is that the brown lenses are less to my liking than I expected. They really give a strong brown/sepia cast to the world compared to the gray lenses I’ve predominantly used in the past. It reminds me a bit of the light on a day with strong wildfire smoke in the air. I wish they offered these same frames but with gray lenses so that this effect wasn’t so pronounced. No stars removed for this since it’s more of a personal preference, but thought I would point it out for anyone who might be more used to gray/natural lenses without realizing it like I was.
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Reviewed in the United States on January 27, 2026
M
Verified Purchase
Madisyn P.
San Leandro, US
★★★★★ 5
GREAT PURCHASE!! Perfect for the beach!
Color: Blue, Size: 7x7 FT (1～3 person)
The perfect beach blanket! I recently purchased this for a trip to Amelia Island in Florida. It did exactly what it was supposed to. Waterproof and sandproof! It even held up in the heat really well. The sand got super hot, but the blanket didn't. Thouroghly pleased! Easy to pack back up, and super light and compact.
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Reviewed in the United States on May 26, 2026
S
Verified Purchase
Suzanne
Omaha, US
★★★★★ 5
Great lightweight beach blanket
Color: Blue, Size: 7x7 FT (1～3 person)
This is a great beach blanket, very well designed. Really lightweight, durable, quick drying, easy to use, packs very small. Stakes are included, but we never use them since the corner pockets filled with sand are sufficient to hold the blanket in place. Folding instructions are also provided, but you can just stuff quickly the blanket into the attached pouch, and the overall fine wrinkles are not an issue -- the blanket still looks very nice. The blanket is very thin, so there's no extra "padding" (this is what keeps it super lightweight and quick drying), but it works great on soft sand, so it's perfect for our use. (This is the first one I've bought, but we've used my son's for years.)
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Reviewed in the United States on March 16, 2026

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