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Description
Phospho-FAK (Tyr397) Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Phospho FAK (Tyr397) Synonyms Focal adhesion kinase 1; FADK 1; Focal adhesion kinase related nonkinase (FRNK); Protein phosphatase 1 regulatory subunit 71 (PPP1R71); Protein tyrosine kinase 2; p125FAK; pp125FAK; FAK; FAK1; PTK2 Immunogen Synthetic Peptide Location Cell membrane, Cytoplasm, Cytoskeleton, Nucleus Accession Q05397 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu, Ms
Product Specification
| Host | Rabbit |
| Antigen | Phospho-FAK (Tyr397) |
| Synonyms | Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase (FRNK); Protein phosphatase 1 regulatory subunit 71 (PPP1R71); Protein-tyrosine kinase 2; p125FAK; pp125FAK; FAK; FAK1; PTK2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cytoplasm, Cytoskeleton, Nucleus |
| Accession | Q05397 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Predicted Reactivity | Ck, Rt, Xe |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
Phospho-FAK (Tyr397) is a crucial phosphorylated form of the focal adhesion kinase (FAK) protein, which plays a significant role in various cellular processes. FAK is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. When phosphorylated at tyrosine residue 397, FAK becomes activated and serves as a binding site for other signaling molecules, such as Src, thereby initiating downstream signaling pathways that are essential for cell motility and the formation of focal adhesions. Dysregulation of Phospho-FAK (Tyr397) has been implicated in several diseases, including cancer, where it contributes to tumor progression and metastasis by enhancing cell invasion and survival.
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