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Description
TACC3 Recombinant Rabbit mAb (S-3048-50)Product Specification Host Rabbit Antigen TACC3 Synonyms Transforming acidic coiled coil containing protein 3; ERIC 1; ERIC1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q9Y6A5 Clone Number S 3048 50 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample RPMI 8226, HeLa, Raji, Ramos, mouse testis, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | TACC3 |
| Synonyms | Transforming acidic coiled-coil-containing protein 3; ERIC-1; ERIC1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | Q9Y6A5 |
| Clone Number | S-3048-50 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | RPMI-8226, HeLa, Raji, Ramos, mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a centrosomal and microtubule-associated protein essential for bipolar spindle assembly and chromosome segregation during mitosis and meiosis. It stabilizes microtubules by forming a complex with ch-TOG (CKAP5) and clathrin, promoting kinetochore-microtubule attachments and preventing spindle multipolarity. TACC3 is frequently overexpressed or involved in oncogenic fusions like FGFR3-TACC3 in various cancers, including bladder, pancreatic, and colorectal cancers, where it drives proliferation, immune evasion, and chemoresistance. Its overexpression disrupts DNA damage response pathways and sensitizes cells to PARP inhibitors, while its depletion induces mitotic catastrophe and cell cycle arrest, making it a promising therapeutic target in oncology.
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