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Description
Human FcGRT&B2M Heterodimer Protein, His TagProduct Specification Species Human Synonyms FcRn, FCGRT & B2M Accession P55899P61769 Amino Acid Sequence Protein sequence (P55899, Ala24 Ser297, with C His Tag) AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSS Protein sequence
Product Specification
| Species | Human |
| Synonyms | FcRn, FCGRT & B2M |
| Accession | P55899、P61769 |
| Amino Acid Sequence | Protein sequence (P55899, Ala24-Ser297, with C-His Tag) AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSS Protein sequence (P61769, Ile21-Met119) IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 32.1 kDa(FcGRT)&11.7 kDa(B2M) Observed MW: 11, 33 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tags & Cleavage sites | with C-His Tag (FcGRT)&No tag (B2M) |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
FcRn is a critical protein responsible for regulating the lifespan and transport of immunoglobulin G (IgG) antibodies. Primarily located in endothelial and phagocytic cells, FcRn binds to IgG in acidic endosomes, recycling them back to the cell surface and releasing them into circulation at a neutral pH. This unique pH-dependent binding mechanism protects IgG from lysosomal degradation, significantly extending its serum half-life. Additionally, FcRn mediates the transcytosis of IgG across placental and epithelial barriers, facilitating passive immunity from mother to offspring and mucosal immune defense. Its role makes it a major therapeutic target for modulating antibody-based therapies.
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