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Description
Alexa Fluor® 488 Mouse Anti-Human CD24 Antibody (S-R576)Product Specification Host Mouse Antigen CD24 Synonyms Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A Location Cell membrane Accession P25063 Clone Number S R576 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD24 |
| Synonyms | Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A |
| Location | Cell membrane |
| Accession | P25063 |
| Clone Number | S-R576 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein A |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD24 is a highly glycosylated cell surface protein that is anchored to the cell membrane via a glycosyl-phosphatidylinositol (GPI) anchor. It is widely expressed in various cell types, including hematopoietic cells such as B cells, T cells, granulocytes, dendritic cells, and macrophages, as well as non-hematopoietic cells like keratinocytes and neurons. CD24 plays a crucial role in immune cell maturation and regulation of immune responses. In cancer, CD24 is overexpressed on tumor cells and interacts with the inhibitory receptor Siglec-10 on immune cells, helping tumor cells evade immune detection and attack. This interaction has led to its exploration as a potential target for cancer immunotherapy, with promising results from clinical trials of monoclonal antibodies and other targeted therapies.
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