SKU: 30305140303

Biotinylated IL-21 R His&Avi Tag Protein, Human

Sale price$193.50 Regular price$215.00
Save 10%

Pay in installments of $53.75 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 17 - Aug 22

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Biotinylated IL-21 R His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms CD360,IMD56,NILR,IL21R,IL 21R Accession Q9HBE5 1 Amino Acid Sequence Cys20 Pro236 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 40 55kDa (Reducing) Purity 95% by SDS PAGE & > 85% by SEC HPLC Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in

Product Specification


Species Human
Synonyms CD360,IMD56,NILR,IL21R,IL-21R
Accession Q9HBE5-1
Amino Acid Sequence

Cys20-Pro236 with His&Avi Tag at the C-Terminus

Expression System HEK293
Molecular Weight 40-55kDa (Reducing)
Purity >95% by SDS-PAGE & > 85% by SEC-HPLC
Conjugation Biotin
Tag Avi Tag, His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Wu Z,et al.(2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
2.Tangye SG. Advances in IL-21 biology - enhancing our understanding of human disease. Curr Opin Immunol. 2015 Jun;34:107-15.
3.Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H. IL-21 receptor is critical for the development of memory B cell responses. J Immunol. 2011 Jan 15;186(2):667-74.

Background

Interleukin-21 receptor (IL-21R) is a type I single-pass transmembrane glycoprotein belonging to the class I cytokine receptor family. Its structure includes an extracellular immunoglobulin-like domain, a conserved WSXWS motif (responsible for proper folding and transport), and an intracellular Box 1 motif (for JAK kinase binding). It must form a functional receptor complex by associating with the common gamma chain (γc). IL-21R is predominantly expressed on lymphohematopoietic cells such as B cells, T cells, and NK cells. Upon binding to its ligand IL-21, it regulates humoral and cellular immunity through signaling pathways such as JAK-STAT, including promoting B cell differentiation into plasma cells and antibody production (e.g., IgG1), enhancing the cytotoxic functions of NK cells and CD8⁺ T cells, and modulating T cell differentiation (e.g., Th17 and regulatory T cells). Abnormal activation of the IL-21R signaling pathway is closely associated with autoimmune diseases (such as systemic lupus erythematosus and allergic dermatitis) and lymphomas (such as diffuse large B-cell lymphoma). By driving the production of pathogenic autoantibodies and excessive activation of immune cells, it contributes to disease pathogenesis, making it an important therapeutic target for autoimmune disorders and hematological malignancies.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 30305140303

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 26 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
J
Verified Purchase
JENNA F.
Port Orchard, US
★★★★★ 3
Smaller than it looks!
Size: 5.75 inch (Pack of 1), Size: 5.75 inch (Pack of 1)
Very very very tiny! I guess they make a larger one I wanted to replace if and this is like 2 inches long haha. I'll give it to my parents Toy poodle. For the price. ..rip off
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 23, 2026
B
Verified Purchase
Beans
Battle Creek, US
★★★★★ 5
Hours of entertainment
Size: 5.75 inch (Pack of 1)
I lived this branch bone for my pups. They like to carry it around and chew on it for hours. Not only does it look cute when they walk around with the branch in their mouth but it keeps them entertained and no mess. Not heavy but I wouldn't suggest throwing it, it would still hurt a bit if it hits one of your shins 😅. Long lasting too
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 20, 2025
C
Verified Purchase
Charles Knippenberg
Bozeman, US
★★★★★ 5
Oh, yes.
Size: 5.75 inch (Pack of 1)
My dog really likes this chew.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 24, 2026
M
Verified Purchase
Miranda Bensch
West Palm Beach, US
★★★★★ 5
They actually last!!!!
Size: 9.5 inch (Pack of 1)
My pitties are CHEWERS!! Most toys don’t last more than a few minutes, if they’re decent then maybe a day or two but these sticks are still going strong!! I ended up getting more cause I was so happy they actually lasted and you can’t beat the price!! My older male is a lot more into toys than my female but now we got a 4 month old bully pup who’s teething and tries to chew on everything!! They are slightly big for him as of right now but he can still easily chew on them and is growing fast -it’s more him trying to run with it in his mouth that is a little hard but they do have smaller options - I love that they can just chew on these for hours and hardly make a dent! If you have aggressive chewers these are a great buy!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 23, 2024
A
Verified Purchase
Amazon Customer
Port Orchard, US
★★★★★ 5
One of the best indestructible dog toys we've bought
Color: 5pack, Size: Large
So we adopted a pup in December and she tears up everything! I mean, Everything! My CPAP, garden hoses, trucks seat belt and backup camera wiring. Every single dog toy with stuffing, dismantle them in minutes. So many dog toys say they are are tear proof. nope! We have tons of stuffing all over our 5 acres. Hen m wife bought these. Beside the bones she bought, these are the only things she can't seem to destroy and she loves them!!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 3, 2026

recommand products