SKU: 30547258584

Tau (phospho T217) Recombinant Rabbit mAb (SDT-R205-TT217-4)

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Description

Tau (phospho T217) Recombinant Rabbit mAb (SDT-R205-TT217-4)Product Specification Host Rabbit Antigen Tau (phospho T217) Synonyms p Tau217, phospho T217 Immunogen Synthetic Peptide Accession P10636 Clone Number SDT R205 TT217 4 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu, Ms Predicted Reactivity Mouse Cross Reactivity Does not recognize total Tau Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage

Product Specification


Host Rabbit
Antigen Tau (phospho T217)
Synonyms p-Tau217, phospho T217
Immunogen Synthetic Peptide
Accession P10636
Clone Number SDT-R205-TT217-4
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu, Ms
Predicted Reactivity Mouse
Cross Reactivity Does not recognize total Tau
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Blood-based biomarkers for Alzheimer’s disease that detect beta-amyloid (Aβ) and phosphorylated tau (pTau) proteinopathy are rapidly developing. The utility and convenience of an accurate blood test has clear implications for accelerating and improving clinical research and practice. Several candidate markers exist including mass spectrometry and immunoassay measured Aβ42 and Aβ40 and their ratio and phosphorylated tau at threonine 217 (pTau217), 181 (pTau181), and other phosphorylated sites, as well as non-specific markers of neurodegeneration and astrogliosis, including neurofilament light (NfL) and glial fibrillary acidic protein (GFAP). Tau is a microtubule-associated protein important for neuronal stability. One of the major neuropathological hallmarks of Alzheimer’s disease (AD) is the hyperphosphorylation of the tau protein which is thought to lead to pathological tau spread and neuronal death. Recent, research studies have shown that plasma levels of p-Tau 217 are elevated in AD patients. Additionally, it has been demonstrated that plasma p-Tau 217 levels are increased in the early stages of the AD continuum and are correlated with amyloid-PET positivity. These findings suggest that p-Tau 217 may serve as a promising blood-based biomarker to aid in AD research, drug development, diagnosis, disease monitoring and patient care. Recently, interest has turned to pTau217, as cerebrospinal fluid levels increase early in autosomal dominant Alzheimer’s disease and better discriminate Alzheimer’s disease from non-Alzheimer’s subgroups of cognitively impaired adults, compared to pTau181. In plasma, pTau217 accurately differentiates persons with neuropathologically defined Alzheimer’s disease from other dementia. Further, in vivo plasma pTau217 levels correlate with ex vivo protein levels and spatial burden in post-mortem brain tissue. Next, plasma pTau217 levels discriminate diagnostic groups informed by amyloid PET. pTau217 levels are elevated among impaired (Alzheimer’s disease or mild cognitive impairment (MCI)) Aβ+ participants compared to cognitively unimpaired (CU) Aβ− participants, and plasma pTau217 and tau PET signal show moderate to high agreement. Serial plasma pTau217 levels also differentiate Alzheimer’s disease from non-Alzheimer’s MCI, remaining stable and non-elevated in Aβ− patients and increasing over time in Aβ+ patients. These findings suggest that p-Tau 217 may serve as a promising blood-based biomarker to aid in AD research, drug development, diagnosis, disease monitoring and patient care.

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SKU: 30547258584

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Milagros Ramos
Pawtucket, US
★★★★★ 4
High quality, perfect color and very nice price!
Size: 14, Color: Brown, Size: 14, Color: Brown
I bought this shoes for my husband's Christmas present, so he didn't try yet. So far, the color is perfect! I feel like he can wear this shoes with different outfits, for the price it seems hight quality, it is not heavy at all. The shoe features a soft, comfortable lining and the sole is perfect because it is non-slip.
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Reviewed in the United States on December 4, 2025
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effie
Dallas, US
★★★★★ 5
Squeaky
Size: 8, Color: Black
They look incredible. But they're a little squeaky. Otherwise my husband loves the comfort. They go with any outfit
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Reviewed in the United States on May 11, 2026
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Boito
Charlottesville, US
★★★★★ 5
These fit very nicely, are comfortable, and work for my wide feet!
Size: 12 Wide, Color: Brown
Once I learned while shoe shopping in my youth that I needed wide-sized shoes, I wasn't able to easily choose from any shoes I saw in the store. I usually have to go find the wide widths and have to deal with the limited styles they have. Shopping online has been hit and miss, too. Sometimes, shoes are advertised as wide width, but end up still being too narrow. These shoes fit me just right. They were not too tight at the toes, gave good width at the arch, and the opening was large enough that I didn't have to undo every single lace just to get my foot in. They also look nice, and I'm sure will take a decent polish. Also, note that this does say it's an Oxford shoe, but it does have the open lacing and is more of a derby-style shoe. This also helps with sizing for my wide feet. If I didn't already have a pair of black shoes, I'd look at picking one of these up. My only reservation with these is that the soles are not dark-colored to complement a more formal style. I feel the white makes them a little more casual. The sole is also more transparent/opaque coloring at the heel and underneath, which you can kind of see-through, so keep that in mind. It's not fully clear, but is kind of transparent, which I was not expecting. I think it also shows where it picks up dirt as you wear it. Just more of a style cue one way or another. As a reference, I buy the 4E wide and Extra Wides in New Balance and Skechers. I also have a hard time getting any good fit in Nike shoes.
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Reviewed in the United States on October 2, 2023
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Michelle sealock
Massapequa, US
★★★★★ 5
Looks and feel good
Size: 10.5, Color: Black
Shoes look dressy but feel comfortable. They are stiff but very comfortable.
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Reviewed in the United States on June 8, 2026
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Riley H.
Battle Creek, US
★★★★★ 5
Well made and affordable
Size: 10.5, Color: Brown
Very comfortable, great price!!!!!!
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Reviewed in the United States on April 30, 2026

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