SKU: 30740821930

SPARCL1 Recombinant Rabbit mAb (S-3326-27)

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Description

SPARCL1 Recombinant Rabbit mAb (S-3326-27)Product Specification Host Rabbit Antigen SPARCL1 Synonyms SPARC like protein 1; High endothelial venule protein (Hevin); MAST 9 Immunogen Recombinant Protein Location Secreted, Extracellular matrix Accession Q14515 Clone Number S 3326 27 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Raji, mouse brain, mouse cerebellum, rat brain Purification Protein A Concentration 2 mg ml Conjugation

Product Specification


Host Rabbit
Antigen SPARCL1
Synonyms SPARC-like protein 1; High endothelial venule protein (Hevin); MAST 9
Immunogen Recombinant Protein
Location Secreted, Extracellular matrix
Accession Q14515
Clone Number S-3326-27
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Positive Sample Raji, mouse brain, mouse cerebellum, rat brain
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:100 Hu

Background

SPARCL1 (secreted protein acidic and rich in cysteine-like 1) is a matricellular heparin-binding glycoprotein of the SPARC family that is secreted by quiescent endothelial cells, astrocytes and other stromal cells, where it functions as a context-dependent modulator of cell–matrix interactions, antagonizing angiogenesis by blocking endothelial proliferation and migration via its N-terminal acidic domain, stabilizing vessel integrity and limiting vascular permeability in colitis and other inflammatory states, while in the brain it promotes excitatory synaptogenesis and astrocyte differentiation, and in cancer it frequently acts as a tumor suppressor whose down-regulation accelerates invasion and metastasis yet, conversely, in gliomas or under viral injury its up-regulation can enhance inflammation by shifting macrophages toward a pro-inflammatory M1 phenotype through TLR4 activation, altogether illustrating a pleiotropic protein that integrates extracellular cues to orchestrate vascular, neuronal and immune homeostasis.

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SKU: 30740821930

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Customer
Draper, US
★★★★★ 5
Great product and price
Great price and works really well. Ford make it a little challenging to change this as you gave to remove the glove box but filter fitted perfectly and the musty smell has gone now.
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Reviewed in the United States on September 18, 2025
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Quick draw
Houston, US
★★★★★ 4
Airflow
A very nice sturdy and colorful filter. The only drawback I have is I think the carbon medium is so thick that it does restricts the airflow a bit. I do notice the air is filtered better than my previous filter, which is why I am keeping it.
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Reviewed in the United States on June 10, 2025
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Malorie
Lake Worth, US
★★★★★ 5
Outstanding Performance, Minimal Installation Guidance Needed
I am delighted to award five stars to the cabin air filter with activated charcoal for my 2022 Chevrolet Tahoe Z71. Installation was a breeze, and it fits my vehicle perfectly. The activated charcoal feature is incredibly effective in eliminating odors and enhancing air quality within the cabin. While the absence of written instructions was a minor inconvenience, a quick reference to the item listing on Amazon provided the necessary guidance for installation. Once in place, the filter performed admirably, ensuring a clean and fresh interior environment. Overall, I wholeheartedly recommend this product to anyone seeking to upgrade their car’s air filtration system. Its exceptional performance and ease of installation make it a standout choice. Five stars without a doubt.
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Reviewed in the United States on March 5, 2024
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Andrea L Long
Lexington, US
★★★★★ 5
As advertised
Perfect fit in my 2015 F150.
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Reviewed in the United States on February 28, 2026
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Amazon Customer
Carnegie, US
★★★★★ 1
Too restrictive!
If you like air flow do not buy this filter. I put it in my 2020 Super duty and had very little air coming out with the fan as high as it would go. Stopped and bought the standard Microguard from Orielly's. I changed it in the parking lot and Bam!!! back to blowing my hat off!
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Reviewed in the United States on May 5, 2026

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