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Description
Invivo anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β mAbProduct Specification Host Mouse Accession P01137P61812P10600 Clone Number 1D11. 16. 8 Antibody Type Mouse mAb Isotype IgG1,k Isotype Control Invivo mouse IgG1 isotype control Application In vivo TGF neutralization, In vitro TGF neutralization Reactivity Hu, Ms, Rt, Mk, Hm, Bv, Dg Purification Protein G Concentration 5 mg ml Purity 95% Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no
Product Specification
| Host | Mouse |
| Accession | P01137、P61812、P10600 |
| Clone Number | 1D11.16.8 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | Invivo mouse IgG1 isotype control |
| Application | In vivo TGF-β neutralization, In vitro TGF-β neutralization |
| Reactivity | Hu, Ms, Rt, Mk, Hm, Bv, Dg |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | ≥95% |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Background
This antibody recognizes the same epitope as clone 1D11.16.8. TGF beta, or Transforming Growth Factor Beta, is a multifunctional protein that plays crucial roles in various physiological processes such as cell growth, differentiation, apoptosis, tissue repair, and immune response. TGF beta stimulates the proliferation and differentiation of various cell types, including fibroblasts, epithelial cells, and endothelial cells. It accomplishes this by activating intracellular signaling pathways that regulate cell cycle progression and differentiation directions. Following injury or tissue damage, the expression of TGF beta significantly increases, participating in the tissue repair and regeneration process. It promotes cell migration, proliferation, and the synthesis of extracellular matrix components, thereby accelerating wound healing. TGF beta can also be involved in tumorigenesis and development in certain circumstances. Abnormal activation of the TGF beta signaling pathway can promote excessive cell proliferation and transformation, contributing to tumor formation and progression.
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