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Description
PDCD4 Rabbit polyclonal antibodyProduct Specification Host Rabbit Antigen PDCD4 Synonyms Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731 like, Protein 197 15a, H731 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q53EL6 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu, Ms, Rt Predicted Reactivity Or Purification Immunogen Affinity Concentration Lot specific*
Product Specification
| Host | Rabbit |
| Antigen | PDCD4 |
| Synonyms | Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, H731 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q53EL6 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or |
| Purification | Immunogen Affinity |
| Concentration | Lot specific* (generally 0.5 to 5 mg/ml)* |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC | 1:400-1:800 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
PDCD4 was considered to encode a nuclear antigen and located on chromosome 10. The expression of PDCD4 is regulated by interleukins IL-2, IL-12, and IL-15. The PDCD4 acts as a tumor-suppressor gene and performs essential functions in many biological events, including apoptosis, protein translation, signal transduction, and stimulation of inflammation mediators. The expression of PDCD4 is tightly regulated at the level of transcription, translation, and protein degradation. The loss of expression of PDCD4 is diagnostic indicator for different human cancers, and is prognostic indicator for survival in cancers of the breast, liver, colon, lung, glioma, and esophagus.
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