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Description
DMC1 Recombinant Rabbit mAb (S-2166-46)Product Specification Host Rabbit Antigen DMC1 Synonyms Meiotic recombination protein DMC1 LIM15 homolog; DMC1H; LIM15 Immunogen Synthetic Peptide Location Nucleus Accession Q14565 Clone Number S 2166 46 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, Raji, K562, Molt 4, F 9, mouse testis, PC 12, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | DMC1 |
| Synonyms | Meiotic recombination protein DMC1/LIM15 homolog; DMC1H; LIM15 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q14565 |
| Clone Number | S-2166-46 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Raji, K562, Molt-4, F-9, mouse testis, PC-12, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Ms, Rt |
Background
DMC1, a meiosis-specific RecA-homologous recombinase conserved from fungi to humans, is indispensable for accurate homologous chromosome segregation during meiosis: it loads onto the single-stranded DNA tails generated at programmed DNA-double-strand breaks, forms octameric rings that encircle the DNA, and drives the search for and strand invasion of homologous chromatids, thereby catalyzing the crossover events that stabilize bivalents; in so doing it works alongside (and partly suppresses) the ubiquitous RAD51, and its absence or mutation causes meiotic arrest, defective synaptonemal-complex formation, and sterility .
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