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Description
Cortactin Recombinant Rabbit mAb (S-1303-10)Product Specification Host Rabbit Antigen Cortactin Synonyms Src substrate cortactin; Amplaxin; Oncogene EMS1; EMS1; CTTN Immunogen Synthetic Peptide Location Cell membrane, Cytoplasm, Cytoskeleton Accession Q14247 Clone Number S 1303 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | Cortactin |
| Synonyms | Src substrate cortactin; Amplaxin; Oncogene EMS1; EMS1; CTTN |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cytoplasm, Cytoskeleton |
| Accession | Q14247 |
| Clone Number | S-1303-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Cortactin is an actin-binding scaffold protein encoded by the human CTTN gene that localizes to membrane ruffles, lamellipodia, invadopodia and other actin-rich structures, where it stabilizes Arp2/3-nucleated branched actin networks through its N-terminal acidic (NTA) domain and tandem repeat region, while its C-terminal SH3 domain recruits multiple binding partners including N-WASP, dynamin-2, and cortactin-binding protein-2 to coordinate cytoskeletal remodeling, endocytosis, cell migration, and extracellular matrix degradation; overexpression or phosphorylation of cortactin—especially at tyrosine residues 421, 466, and 482 by Src family kinases—amplifies these activities, driving tumor cell invasion, metastasis, and resistance to anoikis, and its gene is frequently amplified and its protein overexpressed in a wide range of epithelial cancers, making cortactin both a biomarker of poor prognosis and a potential therapeutic target.
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