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Description
SQSTM1/p62 Recombinant Rabbit mAb (S-R346)Product Specification Host Rabbit Synonyms Sequestosome 1, EBI3 associated protein of 60 kDa (EBIAP, p60), Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin binding protein p62, ORCA, OSIL Location Cytoplasm Accession Q13501 Clone Number S R346 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Synonyms | Sequestosome-1, EBI3-associated protein of 60 kDa (EBIAP, p60), Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, ORCA, OSIL |
| Location | Cytoplasm |
| Accession | Q13501 |
| Clone Number | S-R346 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:20000 | null |
| IHC-P | 1:2000 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype. Mutations in SQSTM1 are a common cause of Paget's disease of bone.
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