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Description
Fc epsilon RII/CD23 His Tag Protein, HumanProduct Specification Species Human Synonyms Low affinity immunoglobulin epsilon Fc receptor; BLAST 2; C type lectin domain family 4 member J; Fc epsilon RII; Immunoglobulin E binding factor; Lymphocyte IgE receptor; CD23; FCER2; CD23A; CLEC4J; FCE2; IGEBF Accession P06734 1 Amino Acid Sequence Asp48 Ser321, with N terminal His Expression System HEK293 Molecular Weight 40 43 kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD23; FCER2; CD23A; CLEC4J; FCE2; IGEBF |
| Accession | P06734-1 |
| Amino Acid Sequence | Asp48-Ser321, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 40-43 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.2 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Low affinity immunoglobulin epsilon Fc receptor (CD23) is a type II membrane protein secreted by single channel. CD23 is a B cell specific antigen and a low affinity receptor of IgE, which plays an important role in regulating the production of IgE and the differentiation of B cells. CD23 exists as a soluble secretory form and then acts as an effective mitotic growth factor. The increase of soluble CD23 level will lead to the recruitment of unsensitized B cells when antigen peptides are presented to sensitized B cells, thus increasing the production of allergen-specific IgE. IgE in turn upregulates the expression of CD23 and Fc epsilon RI (high affinity IgE receptor). Unlike many antibody receptors, CD23 is a C-type lectin expressed on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets. The IgE immune complex binds to CD23 molecules on B cells and transports them to the B cell follicles of the spleen, then the antigen is transferred from CD23+B cells to CD11c+ antigen presenting cells, and CD11c+ cells in turn present the antigen to CD4+T cells, which can lead to enhanced antibody response.
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