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Description
EEA1 Recombinant Rabbit mAb (S-2604-39)Product Specification Host Rabbit Antigen EEA1 Synonyms Early endosome antigen 1; Endosome associated protein p162; Zinc finger FYVE domain containing protein 2; ZFYVE2 Immunogen Synthetic Peptide Location Cytoplasm, Endosome Accession Q15075 Clone Number S 2604 39 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample JAR, Jurkat, HepG2, Daudi, T 47D, NIH 3T3, C6 Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | EEA1 |
| Synonyms | Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2; ZFYVE2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Endosome |
| Accession | Q15075 |
| Clone Number | S-2604-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | JAR, Jurkat, HepG2, Daudi, T-47D, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
EEA1, the 1,400-amino-acid Early Endosome Antigen 1, is a peripheral membrane protein that exclusively decorates early endosomes where it orchestrates endocytic trafficking: via its C-terminal FYVE domain it binds phosphatidylinositol 3-phosphate for membrane recruitment, while its coiled-coil region forms a homodimeric “tether” that, in concert with its N-terminal Rab5-GTP–binding zinc finger, captures incoming Rab5-positive vesicles and aligns them with target membranes prior to SNARE-mediated fusion, thereby linking PI3-kinase signaling to Rab5 regulation of endosome maturation and cargo sorting.
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