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Description
MCM7 Recombinant mAb (SDT-062-18)Product Specification Host Rabbit Antigen MCM7 Synonyms CDC47 homolog,P1. 1 MCM3,CDC47 Immunogen Synthetic Peptide Location Nucleus, Chromosome, Intracellular Accession P33993 Clone Number SDT 062 18 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | MCM7 |
| Synonyms | CDC47 homolog,P1.1-MCM3,CDC47 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Chromosome, Intracellular |
| Accession | P33993 |
| Clone Number | SDT-062-18 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICC | 1:500 | |
| ICFCM | 1:500 | |
| WB | 1:1000 | |
| IP | 1:25 | |
| IHC-P | 1: 500 |
Background
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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