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Description
Caspase-8 (Asp374) Recombinant Rabbit mAb (S-1530-30)Product Specification Host Rabbit Antigen Cleaved Caspase 8 (Asp374) Synonyms Caspase 8; CASP 8; Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP4; FADD homologous ICE ced 3 like protease; FADD like ICE (FLICE); MCH5; CASP8 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q14790 Clone Number S 1530 30 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Cleaved Caspase-8 (Asp374) |
| Synonyms | Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE (FLICE); MCH5; CASP8 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q14790 |
| Clone Number | S-1530-30 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Cleaved Caspase-8 (Asp374) is a key protein involved in the extrinsic apoptosis pathway, which is activated by death receptors such as Fas (CD95) and tumor necrosis factor receptor 1 (TNFR1). When cleaved at Asp374, it generates active fragments, including the p18 subunit, which can further activate downstream effector caspases like caspase-3, -6, and -7, ultimately leading to apoptosis. This protein is also implicated in regulating inflammatory necrotic cell death pathways such as necroptosis and pyroptosis.
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Exchange/Return Notes
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