Pay in installments of $31.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 15 - Aug 20
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Mouse Anti-Human CD124 Antibody (S-3171)Product Specification Host Mouse Antigen CD124 Synonyms Interleukin 4 receptor subunit alpha; IL 4 receptor subunit alpha; IL 4R subunit alpha; IL 4R alpha; IL 4RA; IL4R; IL4RA Location Cell membrane Accession P24394 Clone Number S 3171 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability
Product Specification
| Host | Mouse |
| Antigen | CD124 |
| Synonyms | Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4R; IL4RA |
| Location | Cell membrane |
| Accession | P24394 |
| Clone Number | S-3171 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD124, also known as the interleukin-4 receptor alpha chain (IL-4Rα), is a member of the cytokine receptor superfamily and a key component of Type II cytokine receptors. It primarily functions by forming two distinct types of receptors through pairing with different chains: Type I receptor is composed of CD124 and the common gamma chain (γc), primarily mediating IL-4 signal transduction; the Type II receptor is formed by CD124 and the interleukin-13 receptor alpha 1 chain (IL-13Rα1), which can mediate signals for both IL-4 and IL-13. CD124 plays a central role in activating the JAK-STAT signaling pathway (particularly STAT6), thereby regulating the proliferation, differentiation, and antibody class switching of B cells and T cells, as well as macrophage polarization. It is critically important in allergic responses, inflammation, anti-parasitic immunity, and the tumor microenvironment. Dysregulation of its function is closely associated with allergic diseases such as asthma and atopic dermatitis, as well as certain autoimmune disorders and cancers.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy