SKU: 35080491790

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 35080491790

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4.2 ★★★★★
Based on 22 reviews
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Product Reviews
A
Amazon Customer
Phoenix, US
★★★★★ 5
Well-Made Toy That My Dog Loves, Great Quality and Fun
Color: Alligator(Green), Color: Alligator(Green)
This dog toy has been a great addition to our pup’s collection. It’s well made and feels like solid quality that will stand up to regular play, which is exactly what you want rather than something that falls apart after a few uses. My Havanese absolutely loves it. The size is just right for small to medium-sized dogs, and we’ve had a lot of fun with tug-of-war and gentle fetch sessions. The texture and feel give her something satisfying to bite and carry around. Pros: Well made and durable, feels like it will last through many play sessions. Great size for small to medium dogs like my Havanese. Encourages play and interaction, perfect for tug-of-war and light fetch. Nice value for the quality and price. Easy to grip for both dog and human hands. Cons: Not ideal for extreme chewers; if your dog loves to destroy toys quickly, you might need a super-heavy-duty option. A bit simple in design, no squeaker, but that’s just personal preference. Overall, this is a solid, fun toy that delivers on quality and performance, and my dog genuinely enjoys it. Highly recommend. Still gets 5 stars!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 24, 2026
E
Verified Purchase
ERock
Bozeman, US
★★★★★ 1
Didn't last 5 minutes
Color: Duck(Yellow)
Didn't last 5 minutes with my 9 month old pomeranian. Do not recommend if you have an aggressive chewer.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 24, 2026
M
Verified Purchase
Melissa Franks
West Palm Beach, US
★★★★★ 5
Great hanging toy
Pattern Name: Dog
My dog loves this. We hung it from a tree limb and he plays constantly with it. Lightweight but durable.
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Reviewed in the United States on May 14, 2026
S
Verified Purchase
Stacey H
West Palm Beach, US
★★★★★ 5
Great activity
Pattern Name: Dog
Works great. My male in wall lost interest since she could not win so I just need to rig it so that she wins every once in a while other than that it is great.
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Reviewed in the United States on May 27, 2026
A
Verified Purchase
AJ
Fort Morgan, US
★★★★★ 5
A good idea while it lasted.
Pattern Name: Dog
This toy was a great idea! I thought my Borador (1/2 Lab-1/2 Border Collie) that's constantly full of energy would love it. Unfortunately, he didn't want to play with it at all. Who knows. So I returned it and ordered a herding ball instead.
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Reviewed in the United States on May 16, 2026

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