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Description
Biotinylated PD-L1 Fc&Avi Tag Protein, MouseProduct Specification Species Mouse Synonyms PD L1, B7 homolog 1 (B7 H1), CD274 Accession Q9EP73 Amino Acid Sequence Phe19 Thr238, with C terminal Human IgG1 Fc & Avi Tag
Product Specification
| Species | Mouse |
| Synonyms | PD-L1, B7 homolog 1 (B7-H1), CD274 |
| Accession | Q9EP73 |
| Amino Acid Sequence | Phe19-Thr238, with C-terminal Human IgG1 Fc & Avi Tag FTITAPKDLYVVEYGSNVTMECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 72-83kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Azuma T. et al. (2008) B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 111: 3635. |
Background
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. Mature mouse B7-H1 consists of a 221 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 30 aa cytoplasmic domain. B7-H1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. B7-H1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells.
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4.2 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Well Written and Readable. Highly Recommend
Format: Kindle
I am working on my longest “Days In A Row” reading streak. Finished my last book early with nothing setup to read. Couldn’t find anything that interested me. The 1950’s Red Scare is mentioned often and I only had a high level, general knowledge of that period in history. AND… the Kindle book was on sale for $2. Thought it was worth a shot? The book immediately shot to the top of both my “Best Books” and “Most Informative Books” lists. Highly researched, well organized, incredibly well written and most importantly, readable. If you like history, this is an excellent book on the late 40’s and 50’s. Highly recommend.
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Reviewed in the United States on February 8, 2026
★★★★★ 5
Must-read history to understand the current moment
Format: Hardcover
A fast read, and a fun one (given the topic) Clay Risen's RED SCARE is a major accomplishment. If you don't know much about the Red Scare and McCarthyism, this is a great place to start. If you think you do, you'll learn something and enjoy Risen's meticulously researched account. RED SCARE is also a timely book, providing context for today's MAGA-fueled distrust of DEI and "woke" culture, and the rearguard, "White is right," 1950s mindset that informs it. A must-read book.
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Reviewed in the United States on April 2, 2025
★★★★★ 4
McCarthy and his reach into the modern day
Format: Hardcover
Reasonably even-handed history of McCarthy's rise and fall, the movement he founded, and the people and institutions affected by his influence. A difficult period to read about, though Risen's prose is accessible. A good overview for anyone interested in the period.
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Reviewed in the United States on December 8, 2025
★★★★★ 5
Powerful
Format: Hardcover
Spanning the 40s and 50s, this is an absolutely breathtaking, stunning story of the paranoia, cruelty, and hysteria around an imagined communist-planned takeover of the Unites States by infiltration. This lunacy and oppression occurred at every level of American society from the federal government down to local school boards. Thousands of lives were ruined, more people were killed or committed suicide than you can imagine. It's an ugly story about an ugly time, told like a thriller. I could not stop reading it. My one note is that it was not carefully edited. Every now and then there's a sentence that simply doesn't scan, doesn't make sense, or is awkward--but you could say that points to how good the narrative is overall. Exceptions stick out, and that's too bad, given the subject matter and given that the author thanks an entire large writers' group for helping him with his prose.
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Reviewed in the United States on May 4, 2025
★★★★★ 5
Excellent Look at A.I. and Other Future Technologies
Format: Kindle
This is a fascinating book. Although I bought it to get a better understanding of artificial intelligence (AI), it covers much more. The author also discusses technologies such as 3D printing and vertical farming which are undergoing accelerated development. When discussing these technologies, he cites historical examples to make his point. Although some topics are extremely technical, the author’s writing style makes these concepts easy to understand. The term “singularity” refers to the moment when human consciousness is enhanced beyond our current comprehension.
In the field of nanotechnology, the author discusses a potential increase in human intelligence through virtual neurons such that people will directly interface with the cloud. He also shows how the associated cost is rapidly decreasing. For example, one dollar now buys over 11,000 times as much computing power as it did a decade ago. An astonishing level of reduction. These metrics are then paired with graphs to give the reader a clear picture.
One interesting topic is the concept of mind uploading (aka: whole brain emulation). Computers will be able to simulate human brains in every way within the next two decades. This is followed by what it means to transfer someone’s consciousness into a computer brain. He also discusses the legal implications of a conscious AI and the inability of our political and legal systems to adapt fast enough to enshrine certain rights into law. In the future, biological brains cannot keep up with minds augmented by non-biological nanoengineering.
Equally fascinating is an analysis on how the world has become safer. There is currently less violence and greater literacy than in previous centuries. He then highlights how positive developments never make the news. We only see negative stories because they are newsworthy and entertaining.
Bottom line: This book covers multiple areas of technology and describes how they will likely change our society. It is written in a manner that is easy to understand, and it will definitely open the reader’s eyes to what is coming.
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Reviewed in the United States on October 27, 2025
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