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Description
AMACR/p504s Recombinant Rabbit mAb (SDT-401-29)Product Specification Host Rabbit Antigen AMACR P504S Synonyms Alpha methylacyl CoA racemase, 2 methylacyl CoA racemase Immunogen Synthetic Peptide Location Mitochondrion, Peroxisome Accession Q9UHK6 Clone Number SDT 401 29 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms Purification Protein A Concentration 0. 25 mg ml Tag N A Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | AMACR/P504S |
| Synonyms | Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion, Peroxisome |
| Accession | Q9UHK6 |
| Clone Number | SDT-401-29 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | |
| IHC-P | 1:1000 | |
| ICC | 1:250 | |
| ICFCM | 1:250 |
Background
α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, ibuprofen and related drugs. Protein levels are increased in all prostate and some other cancer cells and it is used as a marker (P504S). The enzyme requires no cofactors and catalyzes its reaction by a stepwise 1,1-proton transfer via an enolate intermediate. The biological role of AMACR in cancer is complex, linking lipid metabolism with nuclear receptor (e.g. FXR and PPAR) activity and expression of enzymes such as cyclooxygenase-2 (COX-2). A number of rationally designed AMACR inhibitors have been reported in the literature as potential cancer treatments. The opportunities and challenges for development of acyl-CoA esters as inhibitors are discussed from a medicinal chemical viewpoint. Other challenges for drug development include the problems in assaying enzymatic activity and the prediction of structure-activity relationships (SAR). [PMID: 23376124]
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