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Description
PEAR1 His Tag Protein, HumanProduct Specification Species Human Synonyms Jedi, PEAR1 Accession Q5VY43 Amino Acid Sequence Leu21 Ser754, with C terminal His Tag Expression System CHO Molecular Weight 80 100kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | Jedi, PEAR1 |
| Accession | Q5VY43 |
| Amino Acid Sequence | Leu21-Ser754, with C-terminal His Tag |
| Expression System | CHO |
| Molecular Weight | 80-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Nanda, N. et al. (2005) J. Biol. Chem. 280:24680. 2.Sun, Y. et al. (2015) Mol Cell Proteomics. 14(5): 1265-1274. 3.Elenbaas, J. et al. (2023) Nat Commun. 14: 850. |
Background
Platelet endothelial aggregation receptor 1 (PEAR1) is a 150 kDa type I transmembrane protein and member of the MEGF family of proteins. Human PEAR1 is synthesized as a 1037 amino acid (aa) precursor that contains a 20 aa signal sequence, a 735 aa extracellular domain (ECD), a 21 aa transmembrane region, and a 261 aa cytoplasmic region. Mature human PEAR1 is 84% aa identical to mature mouse PEAR1. PEAR1 is most highly expressed in platelets and endothelial cells. High affinity immunoglobulin E receptor subunit alpha (Fc epsilon R1 alpha ) has been identified as an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. Inherited PEAR1 variations that alter expression or function of the platelet signaling molecule could modify agonist-induced aggregation in native platelets.
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