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Description
Hyaluronidase PH20/SPAM1 Recombinant Rabbit mAb (S-2143-20)Product Specification Host Rabbit Antigen Hyaluronidase PH20 SPAM1 Synonyms Hyaluronidase PH 20; Hyal PH20; Hyaluronoglucosaminidase PH 20; Sperm adhesion molecule 1; Sperm surface protein PH 20; HYAL3; PH20 Immunogen Recombinant Protein Location Cell membrane Accession P38567 Clone Number S 2143 20 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Human testis, mouse testis, rat testis Purification
Product Specification
| Host | Rabbit |
| Antigen | Hyaluronidase PH20/SPAM1 |
| Synonyms | Hyaluronidase PH-20; Hyal-PH20; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20; HYAL3; PH20 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P38567 |
| Clone Number | S-2143-20 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human testis, mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
Hyaluronidase PH20, also known as SPAM1 (Sperm Adhesion Molecule 1), is a multifunctional glycosyl hydrolase enzyme belonging to the glycosyl hydrolase 56 family. It is a GPI-anchored protein expressed in the testis and found on the surface of mammalian sperm and the inner acrosomal membrane. PH20/SPAM1 is unique for its hyaluronidase activity at neutral pH, which is essential for sperm to penetrate the hyaluronic acid-rich cumulus cell layer surrounding the oocyte during fertilization. Additionally, it plays roles in zona pellucida binding and calcium signaling associated with acrosomal exocytosis. This enzyme is also involved in sperm maturation and has potential applications in reproductive medicine and contraception.
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