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Description
PSME1 Recombinant Rabbit mAb (S-732-14)Product Specification Host Rabbit Synonyms Proteasome activator complex subunit 1, 11S regulator complex subunit alpha (REG alpha), Activator of multicatalytic protease subunit 1, Interferon gamma up regulated I 5111 protein (IGUP I 5111), Proteasome activator 28 subunit alpha (PA28a; PA28alpha) Immunogen Synthetic Peptide Location Cytoplasm Accession Q06323 Clone Number S 732 14 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC,
Product Specification
| Host | Rabbit |
| Synonyms | Proteasome activator complex subunit 1, 11S regulator complex subunit alpha (REG-alpha), Activator of multicatalytic protease subunit 1, Interferon gamma up-regulated I-5111 protein (IGUP I-5111), Proteasome activator 28 subunit alpha (PA28a; PA28alpha) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q06323 |
| Clone Number | S-732-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Pg, Mq |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 | |
| ICC | 1:100 | |
| ICFCM | 1:50 |
Background
Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene. PSME1 is the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. The PSME1 protein plays a crucial role in the assembly of the immunoproteasome and is indispensable for effective antigen processing. As part of the PA28 activator complex, PSME1 collaborates with PSME2 to actively enhance the production of class I-binding peptides by altering the proteolytic cleavage pattern of the proteasome.
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