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Description
SMARCAL1 Recombinant Rabbit mAb (S-2110-328)Product Specification Host Rabbit Antigen SMARCAL1 Synonyms SWI SNF related matrix associated actin dependent regulator of chromatin subfamily A like protein 1; HepA related protein (hHARP); Sucrose nonfermenting protein 2 like 1; HARP s Immunogen Synthetic Peptide Location Nucleus Accession Q9NZC9 Clone Number S 2110 328 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, A549, HeLa,
Product Specification
| Host | Rabbit |
| Antigen | SMARCAL1 |
| Synonyms | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; HepA-related protein (hHARP); Sucrose nonfermenting protein 2-like 1; HARP s |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q9NZC9 |
| Clone Number | S-2110-328 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, A549, HeLa, A431, Jurkat, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:50 | Hu, Ms |
Background
SMARCAL1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like 1) is a DNA-stimulated ATPase and annealing helicase that travels with elongating replication forks and, upon detecting replication stress or DNA damage, catalyzes fork regression to form a protective “chicken-foot” structure and subsequent fork restoration, thereby stabilizing stalled forks, promoting template switching and homology-directed repair, and preventing MUS81-mediated double-strand breaks, while its tight regulation by RPA binding orientation and ATR-dependent phosphorylation of Ser-652 ensures controlled remodeling activity essential for maintaining genome stability, and germline mutations that abolish these functions cause the multisystem disorder Schimke immuno-osseous dysplasia.
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