SKU: 39703748605

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

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Description

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, K562, NIH 3T3, C6 Predicted Reactivity Bv Purification Protein A Concentration 1 mg ml Conjugation HRP Physical Appearance Liquid Storage Buffer PBS,

Product Specification


Host Rabbit
Antigen HDAC1
Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1
Immunogen Synthetic Peptide
Location Nucleus
Accession Q13547
Clone Number SDT-310-72
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, K562, NIH/3T3, C6
Predicted Reactivity Bv
Purification Protein A
Concentration 1 mg/ml
Conjugation HRP
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied.

Dilution


application dilution species
WB 1:10000 Hu, Ms, Rt

Background

Histone deacetylase 1 (HDAC1) is a key enzyme involved in the regulation of gene expression through the deacetylation of histone and non-histone proteins. As a zinc-dependent deacetylase, HDAC1 removes acetyl groups from lysine residues on histones, thereby tightening chromatin structure and inhibiting gene transcription. It is a component of several multiprotein complexes, such as the NuRD complex, which are involved in chromatin remodeling and transcriptional repression. HDAC1 plays a crucial role in various cellular processes, including cell cycle progression, differentiation, and development. In cancer, HDAC1 is often overexpressed and contributes to tumor progression by promoting cell proliferation and survival. For example, in colorectal cancer, HDAC1 enhances cell survival and proliferation in an ATG16L-dependent manner. Additionally, HDAC1 overexpression in cancer cells can be regulated by transcription factors like Sp1 and Sp3, which bind to the HDAC1 promoter and recruit other epigenetic modulators. In neurodegenerative diseases such as Alzheimer's disease, HDAC1 has been implicated in the regulation of oxidative DNA damage repair and synaptic function. Studies have shown that HDAC1 activity may be involved in the pathogenesis of Alzheimer's disease through its effects on DNA repair mechanisms and gene expression. HDAC1 is also a potential therapeutic target for neurological disorders, as HDAC inhibitors have shown promise in preclinical studies for treating conditions like Huntington's disease and Parkinson's disease.

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SKU: 39703748605

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4.2 ★★★★★
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Product Reviews
J
Verified Purchase
Jacki Torres
Houston, US
★★★★★ 4
Functional and Good Quality
Color: 01-silver, Color: 01-silver
I give this SMARTAKE paper towel holder 4 stars. Overall, it's a very good product that I would recommend, but it has one minor drawback that takes away a star. The Positives Quality and Stability: The holder feels good quality, and the material (steel) is sturdy. Once placed on the counter, it's stable and adheres well to the surface. Assembly and Use: It was easy to put together; just read the instruction manual. I confirm that it works well even with large paper towel rolls. Furthermore, it's not difficult to change the roll at all. The Drawback The only problem is the small mechanism that's supposed to adjust and hold the roll (the piece that prevents it from twisting too much). As the paper gets used up, this piece doesn't do its job properly, and the paper unwinds more than it should. Conclusion: If you're looking for a modern, stable, and well-made holder for your kitchen, this is excellent. Just keep in mind that the adjuster isn't the best, but other than that, it does its job perfectly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 18, 2025
P
Verified Purchase
Patty C
Natrona Heights, US
★★★★★ 5
Durable and nice look
Color: 02-black
Nice quality and nice look for our kitchen
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 30, 2026
K
Verified Purchase
K. K.
Grantham, US
★★★★★ 5
Classic holder keeps paper towels in place in a breeze.
Color: 06-bronze
This classic paper towel holder works perfectly. I had constantly unrolling paper towels in the breeze. This holder keeps everything in place now. So nice. Plus, it has a sleek, uncluttered design. I’m very pleased.
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Reviewed in the United States on May 18, 2026
T
Verified Purchase
Terry Anne
Cuba, US
★★★★★ 3
Only holds towels in place when it is full or 1/2 full
Color: 01-silver
If you are buying this for the feature of holding the paper towels in place so you can just rip one, I think you will be disappointed. Once the roll becomes smaller (and I tried changing the arm) the arm does not touch the towels. I do like the firm grip on the counter. My other dissatisfaction is the base gets water spots. Being near the sink this happens frequently. It does its job and is attractive.
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Reviewed in the United States on May 21, 2026
J
Verified Purchase
Jay
Birmingham, US
★★★★★ 5
Stylish
Color: 01-silver
Good sturdy stand for paper towels. Has small suction cups on bottom for stability. Good finish and good fit under the counter. Heavy base and not flimsy feeling. Brushed aluminum matched other appliances well.
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Reviewed in the United States on January 6, 2026

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