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Description
Her2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Her2, ERBB2, CD340, HER 2 neu, MLN19, NEU, NG, TKR1 Accession P04626 1 Amino Acid Sequence Thr23 Thr652, with C hIgG1 Fc Expression System HEK293 Molecular Weight 110 120kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | Her2, ERBB2, CD340, HER-2/neu, MLN19, NEU, NG, TKR1 |
| Accession | P04626-1 |
| Amino Acid Sequence | Thr23-Thr652, with C-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 110-120kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Schlessinger J. (2000) Cell Signaling by Receptor Tyrosine Kinases. Cell. 103(2): 211-225. 2、Codony-Servat J et al. (1999) Cleavage of the HER2 Ectodomain Is a Pervanadate-activable Process That Is Inhibited by the Tissue Inhibitor of Metalloproteases-1 in Breast Cancer Cells. Cancer Res. 59(6): 1196-1201. |
Background
The HER2/neu gene is one of the family of genes encoding transmembrane receptors for four growth factors, including the epidermal growth factor receptor (EGFR), HER2/neu, HER3, and HER4. The HER2/neu gene is localized on the long arm (q21) of chromosome 17. This gene codes for a 185 kDa receptor-type tyrosine protein kinase (p185 neu or c-erbB-2) similar to EGFR. This 1255 amino acid transmembrane glycoprotein is composed of three domains: an extracellular factor-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. The intracellular domain of HER2/neu has tyrosine kinase activity, which regulates cell growth and proliferation. HER2/neu is over-expressed in 20-25% of invasive breast cancers and is associated with an aggressive tumor, early relapse, and reduced survival.
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