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Description
Alexa Fluor® 488 Mouse Anti-Rat CD45RA Antibody (S-R629)Product Specification Host Mouse Antigen CD45RA Synonyms Leukocyte common antigen; high molecular weight form Location Cell membrane Accession 24699 Clone Number S R629 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Mouse |
| Antigen | CD45RA |
| Synonyms | Leukocyte common antigen; high molecular weight form |
| Location | Cell membrane |
| Accession | 24699 |
| Clone Number | S-R629 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Rt |
Background
CD45RA protein is a specific isoform of the CD45 receptor, also known as protein tyrosine phosphatase receptor type C (PTPRC), which is generated through alternative splicing of the CD45 gene. It is a marker for naive T cells and central memory T cells (TCM), characterized by the presence of exon 4 (A) but the absence of exons 5 (B) and 6 (C) in its mRNA. CD45RA is expressed on the surface of nucleated hematopoietic cells, including B cells, NK cells, naive/resting T cells, medullary thymocytes, and plasmacytoid dendritic cells. It plays a crucial role in the immune system by modulating T cell receptor (TCR) and B cell receptor (BCR) signaling pathways, facilitating the activation and proliferation of immune cells. In adults, CD45RA+ cells may help prevent autoimmune diseases, while reduced numbers of CD45RA+ CD4+ T cells have been associated with conditions such as biliary atresia, primary biliary cirrhosis, fetal distress, and preeclampsia. Pathologists use CD45RA to differentiate naive T cells (CD45RA+) from memory T cells (CD45RO+), although this distinction may not be applicable in adult allogeneic hematopoietic cell transplant recipients.
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