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Description
Biotin Mouse Anti-Human CD1d Antibody (S-2874)Product Specification Host Mouse Antigen CD1d Synonyms Antigen presenting glycoprotein CD1d; R3G1; CD1D Location Cell membrane, Endoplasmic reticulum membrane Accession P15813 Clone Number S 2874 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD1d |
| Synonyms | Antigen-presenting glycoprotein CD1d; R3G1; CD1D |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | P15813 |
| Clone Number | S-2874 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD1d is a transmembrane glycoprotein that belongs to the group 2 CD1 family of non-classical MHC class I-like antigen-presenting molecules, expressed on dendritic cells, thymocytes, hepatocytes and many other tissues; it forms a heterodimer with β2-microglobulin, folds into a deep, hydrophobic groove made up of A′ and F′ pockets that cradle lipid tails while exposing the glycosyl headgroups of self or microbial glycolipids, and delivers these antigens to the invariant T-cell receptor of CD1d-restricted natural killer T (iNKT) cells, thereby rapidly triggering large bursts of cytokines such as IFN-γ and IL-4 that shape innate and adaptive immune responses against infections, cancer, and autoimmune diseases.
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