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Description
SIGMAR1 Recombinant Rabbit mAb (S-2079-270)Product Specification Host Rabbit Antigen SIGMAR1 Synonyms Sigma non opioid intracellular receptor 1; Aging associated gene 8 protein; SR31747 binding protein (SR BP); Sigma 1 type opioid receptor (SIG 1R; Sigma1 receptor; Sigma1R; hSigmaR1); OPRS1; SRBP Immunogen Synthetic Peptide Location Cell membrane, Nucleus membrane, Endoplasmic reticulum membrane Accession Q99720 Clone Number S 2079 270 Antibody Type Recombinant mAb Isotype IgG Application WB,
Product Specification
| Host | Rabbit |
| Antigen | SIGMAR1 |
| Synonyms | Sigma non-opioid intracellular receptor 1; Aging-associated gene 8 protein; SR31747-binding protein (SR-BP); Sigma 1-type opioid receptor (SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1); OPRS1; SRBP |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Nucleus membrane, Endoplasmic reticulum membrane |
| Accession | Q99720 |
| Clone Number | S-2079-270 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, 293T, Caco-2, NIH/3T3, mouse liver, mouse brain, C6, rat liver, rat brain, COS-7 |
| Predicted Reactivity | Bv, GP, Ft |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| ICC | 1:100 | Hu, Ms |
| FCM | e |
Background
The SIGMAR1 protein, also known as the sigma-1 receptor, is a multifunctional chaperone protein composed of 223 amino acids with a molecular mass of 25.3 kDa. It is encoded by the SIGMAR1 gene and is ubiquitously expressed in various tissues, including the brain, heart, liver, and kidneys. SIGMAR1 is primarily located in the mitochondria-associated endoplasmic reticulum membrane (MAM), where it regulates calcium signaling, ion channel activity, and mitochondrial function. This protein plays a crucial role in cellular survival and has been implicated in several diseases, such as neurodegenerative disorders (e.g., amyotrophic lateral sclerosis and Alzheimer's disease), cardiovascular diseases, and certain cancers. Additionally, SIGMAR1 has been shown to have protective effects against neuronal and cardiac injuries.
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