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Description
NG2/CSPG4 His Tag Protein, HumanProduct Specification Species Human Synonyms neuron glial antigen 2, NG2, high molecular weight melanoma associated antigen, HMW MAA) Accession Q6UVK1 Amino Acid Sequence Ser1583 Ser2224, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | neuron-glial antigen 2, NG2, high molecular weight-melanoma associated antigen, HMW-MAA) |
| Accession | Q6UVK1 |
| Amino Acid Sequence | Ser1583-Ser2224, with C-terminal 10*His SLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVNVTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRARTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDFATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEANMFSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 90-110 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
CSPG4 (also known as neuron-glial antigen 2, NG2, and high molecular weight-melanoma associated antigen, HMW-MAA) is key component of cell migration and proliferation. CSPG4 has been associated with disease severity in other tumors. Expression of CSPG4 could be a useful prognostic biomarker in chordoma. As CSPG4 is expressed on the cell-surface, it is also an attractive candidate for targeting by a CSPG4-specific antibody.
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4.7 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 4
Worked well, comfortable.
Style: Bundle, Size: 2 Piece Set
These patches adhere fairly well to my chin, over a very large cystic pimple. I admit, the microneedle patches I used before caving and picking were the Kill brand, not Rael. I figured I would buy both on the off chance I ised all the Kill stickers (whose price tag is honestly ridiculous). After the zit popped though, I found this brand to be preferrable to my usual HERO staple for a number of reasons:
1) While the hero patches are bigger and thicker, this brand was more comfortable to wear long term. As I was treating during my work day, I felt more confident with these thin, flexible sheets than with other brands. They're thinner, but seem to work just as well and are more comfortable.
2) They're practically invisible on my face. Now, it's not really possible to make these things disappear entirely. Because they're thinner, they do wrinkle some when I speak and tend to stretch on the skin. I will say that this recurring zit does live on my chin, so there may be more movement and wear as a result.
3) I feel less inclined to change them early. Because they wear so well, this brand was much less noticable on my face. I couldn't feel it and in fact, forgot it was there until I took a bathroom break. That made it easier to focus on getting work done rather than worrying about how it felt or looked. I did wear a tiny bit of concealer over these and no one seemed to notice.
Overall, pretty good product.
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Reviewed in the United States on March 12, 2020
★★★★★ 5
Magic Spots make your acne..DISAPPEAR!
Style: Bundle, Size: 2 Piece Set
I like this product. I was nervous cause I am allergic to everything. However I got an ingrown pimple right under my nose. It hurt like a mother. So I bought these in hopes it would eat it off my face and I was pleasantly surprised. I put the one that has the crystals under my nose overnight. This morning it ate all the sebum around it and left a weak white head. When I removed the white head, I had a pretty decent hole under my nose. I put a dot from the pink box on it after disinfecting it and drying it off in hopes it will keep it protected while I wear a mask at work. I also had one in pink box on the side of my face in hopes of helping a ragged acne that I had scratched of the scab in my sleep the night before. So it was pretty rough skin. I slapped the dot from the pink box over night as well and my skin is soft. Its still a little red from where it was but its not raised and it doesn't hurt. These are pretty awesome. The adhesion sticks all night did not move ONCE. It was almost like removing a bandaid. They stretch well and fit over most acne spots and they are thick enough to not tear easy and hold all the gross that comes out of your face. I had no real expectations of the product because I wasn't sure how this face magic worked but it definitely does the trick when you have painful ingrown and just stubborn acne spots.
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Reviewed in the United States on February 3, 2021
★★★★★ 3
They work, but not really worth it
Style: Bundle, Size: 2 Piece Set
Off the bat, they work pretty well. It’s not a miracle and they do work but I’d look for something else before buying these again. The micro needle ones did help deeper acne but they break way too easily to justify buying.
The packaging sucks and is confusing. The micro needle dots are two parts that work awfully together. I broke 2 of the 9 just trying to get them off the package. The miracle dots are slightly better but if you get it stuck to your finger trying to get it off, that dot’s a wash.
The adhesive is good in some places and not so good at the edges. A few stayed on well and those that did were nicely transparent. These are not invisible but I’d run out with one on and I have darker skin.
I took them off and noticed that fluid had been drawn out and overall, things were flatter and more calm. However, the amount of these things I threw away due to the awful packaging and just not adhering, I’d have to be at a last ditch effort to buy these again.
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Reviewed in the United States on January 25, 2020
★★★★★ 5
They really do work, although it's a little hard to peel them off the backing.
Style: Bundle, Size: 2 Piece Set
I bought this combo pack because I had one of those deep cysts on my chin that I knew wasn't coming out anytime soon. I already knew the hydrocolloid patches for whiteheads would work, because hydrocolloid bandages work just fine for drawing things out of zits that have come to a head. I was more reluctant about the deep patches, with the microneedles, because it just seemed like nonsense that couldn't possibly work.
They DO work! I put one on that deep cyst and when I woke up, it was 75% smaller than it had been when I went to bed. I couldn't believe it. I was so impressed that I actually said so out loud, to myself, alone, in my bathroom. Normally, that thing would've stuck around for weeks, getting angrier and redder but never coming to a head. I used one again the next night, and in the morning, it was pretty much gone, and it never came back. I highly recommend these.
One issue I have with them is that peeling them off the backing it a bit of a delicate process. You have to be careful not to fold the edge over onto itself, which is easy to do because they're so small and thin. You also have to make sure to place them in the exact right place the first time. But despite these problems, I still gave them 5 stars because they work so well, so there's that.
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Reviewed in the United States on March 18, 2020
★★★★★ 5
Worked like a charm
Style: Bundle, Size: 2 Piece Set
I’ve tried other acne patches before and they’ve always pulled excess oil out of my pores, which ended up drying, scarring, and leaving behind a dry patch when compared to the rest of my face. These effects were especially bad for my cystic acne, which always ended up more inflamed and painful after treatment.
The Rael hydrocolloid patches gently pulled out all of the sebum from several pimples that I’d avoided picking at; with other brands, the patches only pulled anything out from pimples that had already been picked at/burst. The micro needle patch also relieved my cystic acne overnight. The pimple is no longer inflamed or painful. When I took the patch off, I could see the liquid and oils that it had pulled out BUT didn’t experience the scarring I have with other patches. Other reviews mention that the patches are fragile, but I don’t necessarily think that’s any different from the other brands I’ve tried. I had no problem trying to get one out of the package on the first try.
Overall, I think these are a really good fit for folks with oily skin who experience scarring with other patches. These definitely pull more sebum and not as much oil, so you should see your pimples decrease in size without adding to the inflammation. The patches adhere well and stayed on all night without peeling off (even though I’d accidentally bunched up some edges on the hydrocolloid patches when applying). I’m definitely going to keep a stock of both types readily available!
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Reviewed in the United States on February 23, 2020