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Description
UBE2F Recombinant Rabbit mAb (S-2672-26)Product Specification Host Rabbit Antigen UBE2F Synonyms NEDD8 conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8 conjugating enzyme 2; RING type E3 NEDD8 transferase UBE2F; Ubiquitin conjugating enzyme E2 F; NCE2 Immunogen Synthetic Peptide Location Nucleus Accession Q969M7 Clone Number S 2672 26 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | UBE2F |
| Synonyms | NEDD8-conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F; NCE2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q969M7 |
| Clone Number | S-2672-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Jurkat, A375, HeLa, HL-60, NTERA2, RAW264.7, NIH/3T3, mouse testis, rat ovary, rat testis |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
| ICFCM | 1:50 | Hu, Ms |
Background
UBE2F (ubiquitin-conjugating enzyme E2 F) is a NEDD8-specific E2 conjugating enzyme that, following activation by the NAE1–UBA3 heterodimer, transfers NEDD8 onto CRL5–RBX2/SAG complexes to catalyze CUL5 neddylation, thereby activating CRL5 E3 ligase activity and promoting K11-linked polyubiquitylation and proteasomal degradation of the pro-apoptotic protein NOXA, a pathway that is frequently up-regulated in non-small-cell lung cancer to suppress apoptosis and drive tumor survival, and whose oncogenic action can be pharmacologically targeted to enhance chemotherapy sensitivity.
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