SKU: 43596975554

IFN-alpha/beta R1 His Tag Protein, Human

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Description

IFN-alpha/beta R1 His Tag Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFNAR,CRF2 1,IFN R 1,IFNAR 1,IFNBR Accession P17181 1 Amino Acid Sequence Lys28 Lys436 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 70 95kDa (Reducing) Purity 95% by SDS PAGE & > 95% by SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the

Product Specification


Species Human
Synonyms IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1,IFNBR
Accession P17181-1
Amino Acid Sequence

Lys28-Lys436 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight 70-95kDa (Reducing)
Purity >95% by SDS-PAGE & > 95% by SEC-HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Groen K, Kuratli R, Enkelmann J, Fernbach S, Wendel-Garcia PD, Staiger WI, Lejeune M, Sauras-Colón E, Roche-Campo F, Filippidis P, Rauch A; Swiss HIV Cohort Study; Trkola A, Günthard HF, Kouyos RD, Brugger SD, Hale BG. Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. J Exp Med. 2025 Jun 2;222(6):e20242039.
2.Amendolara R, D'Onofrio L, Sessa RL, Di Giulio S, Mignogna C, Coraggio L, Schirano R, Zampetti S, Malandrucco I, Pozzilli P, Giannini G, Maddaloni E, Buzzetti R. IFN-α Neutralizing Antibodies Distinguish LADA From Early-onset Type 1 Diabetes. J Clin Endocrinol Metab.
3.Abramovich C,et al.(1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

Background

Interferon α/β receptor 1 (IFNAR1) is a key component of the type I interferon (IFN-α/β) receptor. It belongs to the type II cytokine receptor family and is a type I transmembrane protein. Its extracellular region contains four fibronectin type III domains. IFNAR1 must form a functional receptor complex with another subunit, IFNAR2, to mediate type I interferon signal transduction. Upon ligand binding, the receptor activates downstream JAK kinases (such as Tyk2), which in turn phosphorylate transcription factors such as STAT1 and STAT2, initiating the expression of antiviral and immunomodulatory genes. Research suggests that its signaling mechanisms are complex: on the one hand, under specific conditions (such as during IFN-β signaling), IFNAR1 can function independently without relying on IFNAR2, and this pathway may not involve the classical JAK-STAT pathway; on the other hand, Tyk2 can stabilize IFNAR1 expression by inhibiting its endocytosis, while mutations at key tyrosine sites (e.g., Tyr466) can block STAT phosphorylation in a dominant-negative manner, confirming the central role of IFNAR1 in linking JAK and STAT. IFNAR1 itself also possesses direct antiviral activity.As the gateway for type I interferon signaling, IFNAR1 is a critical target in antiviral immunity, autoimmune diseases, and tumor immunotherapy. Hyperactivation or abnormal signaling of the receptor is associated with autoimmune diseases (such as systemic lupus erythematosus), while functional defects may increase susceptibility to viral infections. Modulation of this receptor and its signaling pathway provides important directions for the development of antiviral drugs, therapies for autoimmune diseases, and novel immune adjuvants.

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SKU: 43596975554

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4.4 ★★★★★
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RR
Massapequa, US
★★★★★ 5
So Far So Good
I adopted a young adult dog less than 2 weeks ago. She had spent over 12 hours a day in a crate and has excessive energy and anxiety built up. She is a strong chewer. So far, out of 6 toys, this is the only one still in one piece. It appears sturdy and extra bouncy. So much better than regular tennis balls.
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Reviewed in the United States on January 17, 2024
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Lisa B
Carnegie, US
★★★★★ 5
My dogs favorite!
My dogs love these! They will play all day if you'd let them, these balls are their favorites. I use the chuck-it handle and they get tons of exercise in the big yard!
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Reviewed in the United States on April 22, 2026
T
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Theredirishman
Phoenix, US
★★★★★ 5
The Dog LOVES IT!
I bought this for my ex-wife's Pitbull. He is an aggressive chewer and usually destroys any toy I buy him. But not this one! The ball is small enough and pliable that it gives when he chomps on it. He loves this ball and seems to be his favorite toy. Thank you for making a product that he likes and can't destroy!
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Reviewed in the United States on December 30, 2024
S
Verified Purchase
Sean
West Palm Beach, US
★★★★★ 5
My Golden Retriever’s favorite
We’ve owned lots of toys and balls. This specific version (in blue) has been her absolute favorite. She’s about 72lbs and chews on this thing regularly with no visible damage. We actually own about 6 of them because they have a tendency to go missing underneath furniture and in the yard. We have two of the orange colored ones but she doesn’t like those nearly as much which I assume is because the blue is easier to see in the grass. Other than that…They bounce really well and also whistle a little when you throw them hard enough. I hope they never stop making these.
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Reviewed in the United States on October 6, 2024
A
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Alp acct
Lexington, US
★★★★★ 4
doesn't whistle as loud as other chuckit balls I've seen, but a good ball.
makes some noise, but I've seen (and played with) others at the dog park that whistle much louder than the 1 I got. all Chuckit balls... so, just this one I'm betting. but it flys good and the dog loves to chase it. he chews it a fair bit as well and the ball has not taken much damage from him (lab mix) or others that have had a go at it. I'll likely buy another at some point ... just wish it was a little louder when flying.
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Reviewed in the United States on November 4, 2025

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