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Description
S-RMab® CD8α Mouse mAb (SDT-1036-34)Product Specification Host Mouse Antigen CD8 Synonyms T lymphocyte differentiation antigen T8 Leu 2, T cell surface glycoprotein CD8 alpha chain, MAL, CD8a Immunogen Recombinant Protein Location Cell membrane Accession P01732 Clone Number SDT 1036 34 Antibody Type Mouse mAb Isotype IgG1,k Application IHC P, ICC, FCM, IF Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Mouse |
| Antigen | CD8α |
| Synonyms | T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain, MAL, CD8a |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P01732 |
| Clone Number | SDT-1036-34 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | IHC-P, ICC, FCM, IF |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| ICC | 1:500 | |
| IF | 1:1000 | |
| FCM | 1:2000 |
Background
CD8A encodes the CD8 alpha chain of the αβT cells, proposed as a quantifiable indicator for CD8+ CTL recruitment or activity assessments and a robust biomarker for responses to anti-PD-1/PD-L1 therapy. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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Exchange/Return Notes
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