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Description
IFN-α 2a Protein, HumanProduct Specification Species Human Synonyms Leukocyte interferon. B cell interferon, Type I interferon, IFNA2, IFN a 2a Accession P01563 Amino Acid Sequence Cys24 Glu188 Expression System E. coli Molecular Weight 17 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 150mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | Leukocyte interferon. B cell interferon, Type I interferon, IFNA2, IFN-a 2a |
| Accession | P01563 |
| Amino Acid Sequence | Cys24-Glu188 |
| Expression System | E.coli |
| Molecular Weight | 17 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cytokine. 2011 Jan;53(1):52-9. |
Background
IFN-α is a cytokine that has an immunomodulatory function. It plays an important role not only in antiviral activity but also in several physiologic functions, such as activation of dendritic cells and accelerated expression of major histocompatibility complex I and II molecules that may cause increased antigen presentation. Variants of human leukocyte interferon α 2 (IFN-α 2a, α 2b, and α 2c) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. IFN-α 2a is an important cytokine and used for antiviral and anticancer treatment.
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