SKU: 47219130516

CD117/c-Kit Fc Chimera Protein, Mouse

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Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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SKU: 47219130516

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bearofdeath
Belleville, US
★★★★★ 5
Great book
Format: Paperback
Easy, quick read. Good book and very cool to read/practice!
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Reviewed in the United States on September 25, 2018
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Dana J. Sheffield
Draper, US
★★★★★ 5
Great information!
Format: Paperback
Great information!
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Reviewed in the United States on September 20, 2019
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Susan
Massapequa, US
★★★★★ 5
Five Stars
Format: Paperback
love it
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Reviewed in the United States on March 1, 2018
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Sherin
Pawtucket, US
★★★★★ 3
Simple, Straightforward and Concise - Ideal for Beginners!
Format: Kindle
Written by Sophie Merle, The Book of Tapping: Emotional Acupressure with EFT is a short, concise and simple but straightforward guide to Tapping. What I liked best about this book is that - it is very easy to understand, making it possible for anyone and everyone to explore EFT. Since this is a very short book, I understand that not much is covered, just the basics predominantly, but if you are looking for an introduction to EFT Tapping and uncomplicated explanations and ideas, this is a book you can check out! **I was offered an eARC by Healing Arts Press through Net Galley in exchange for an honest review.
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Reviewed in the United States on April 24, 2017
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Joseph J. Truncale
Alexandria, US
★★★★★ 5
An excellent basic text for anyone interested in learning the EFT system.
Format: Paperback
Over the years I have read a several books on the healing art of tapping and I must say this 106 page soft cover volume (The book of Tapping: Emotional acupressure with EFT by Sophie Merle) is one of the best I have read lately. The step-by-step lessons are easy to follow and everything is explained in a clear and concise way. This book is organized into ten sections covering the following material: EFT: an energetic technique for health and material abundance, the EFT protocol, working with EFT, a collection of painful statements, the body’s meridians and their emotional function, the various ways EFT can be applied, EFT and the realization of goals, group sessions, two EFT variations and a conclusion. If you are seeking a good basic introduction to the EFT system you may want to check out this excellent book. Rating: 5 Stars. Joseph J. Truncale (Author: Chair/Seated Tai Chi, Qigong and Yoga stretching for seniors and the physically challenged).
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Reviewed in the United States on February 2, 2019

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