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Description
PLK1 Recombinant Rabbit mAb (S-2835-32)Product Specification Host Rabbit Antigen PLK1 Synonyms Serine threonine protein kinase PLK1; Polo like kinase 1 (PLK 1); Serine threonine protein kinase 13 (STPK13); PLK Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus Accession P53350 Clone Number S 2835 32 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample Ramos, HepG2, HeLa, HEK 293, Jurkat, mouse testis, PC 12, rat testis,
Product Specification
| Host | Rabbit |
| Antigen | PLK1 |
| Synonyms | Serine/threonine-protein kinase PLK1; Polo-like kinase 1 (PLK-1); Serine/threonine-protein kinase 13 (STPK13); PLK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | P53350 |
| Clone Number | S-2835-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | Ramos, HepG2, HeLa, HEK-293, Jurkat, mouse testis, PC-12, rat testis, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu |
Background
PLK1 (Polo-like kinase 1) is a 603-residue serine/threonine kinase that peaks in late G2/M where it docks to phosphorylated Bub1 and the PBD-binding p-T78 motif on its own T-loop to auto-activate, then successively phosphorylates Cdc25C, Cyclin B1, Wee1, APC/C-Cdc20, and myriad kinetochore proteins to drive centrosome maturation, bipolar spindle assembly, chromosome alignment, the spindle-assembly and decatenation checkpoints, and timely mitotic exit, while its deregulated overexpression in cancers creates chromosomal instability and chemoresistance, making it a high-priority drug target whose ATP-competitive inhibitors (BI 2536, volasertib) are already in oncology trials.
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