SKU: 47648620333

ASGR2 Recombinant Rabbit mAb (SDT-2059-47)

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Description

ASGR2 Recombinant Rabbit mAb (SDT-2059-47)Product Specification Host Rabbit Antigen ASGR2 Synonyms Asialoglycoprotein receptor 2; ASGP R 2; ASGPR 2; C type lectin domain family 4 member H2; Hepatic lectin H2 (HL 2); CLEC4H2 Immunogen Synthetic Peptide Location Membrane Accession P07307 Clone Number SDT 2059 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HepG2, human hepatocellular carcinoma, human liver Predicted Reactivity Purification

Product Specification


Host Rabbit
Antigen ASGR2
Synonyms Asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; C-type lectin domain family 4 member H2; Hepatic lectin H2 (HL-2); CLEC4H2
Immunogen Synthetic Peptide
Location Membrane
Accession P07307
Clone Number SDT-2059-47
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample HepG2, human hepatocellular carcinoma, human liver
Predicted Reactivity /
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

The ASGR2 protein (Asialoglycoprotein Receptor Subtype 2) is a type II transmembrane receptor primarily expressed on the surface of hepatocytes and belongs to the C-type lectin superfamily. It forms hetero-oligomeric complexes with ASGR1, mediating the endocytosis and lysosomal degradation of desialylated glycoproteins in the bloodstream by recognizing terminal galactose or N-acetylgalactosamine residues. This process plays a critical role in maintaining glycoprotein homeostasis and regulating cholesterol metabolism. ASGR2 exhibits liver-specific high expression, featuring a calcium-dependent carbohydrate-recognition domain (CRD) in its extracellular region. Recent studies have identified the ASGR signaling pathway's involvement in lipid metabolism disorders, liver fibrosis, and hepatocellular carcinoma progression. Targeted therapies (e.g., ASGR1/2 inhibitors) show potential for cholesterol-lowering treatments, possibly by modulating the PCSK9/LDLR pathway. Additionally, ASGR2 is utilized in designing liver-targeted drug delivery systems, leveraging its efficient internalization capacity to enhance liver-specific accumulation of therapeutic molecules.

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SKU: 47648620333

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4.0 ★★★★★
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Product Reviews
J
Verified Purchase
Jon Parshall
Natrona Heights, US
★★★★★ 5
Groundbreaking Work!
Format: Hardcover
The first thing to note here is the author is trilingual. He's Polish by birth, writing very credibly in his second language (English), and using his Nihongo to translate Japanese source materials into English for the first time. Wow! As a historian myself, I only wish I had those kind of language skills. The second thing I'll say is that I learned a lot from the book. I've never seen many of the details the author had dug up. He's doing the same sort of thing that Tony Tully and I did in Shattered Sword--using the Japanese air group records, and Senshi Sosho, as well as more modern sources from Japanese historians like Mori Shiro--to paint a much richer picture of the Japanese side of the battle. And in some ways he's doing it better, because his language skills are so formidable that he was able to look at more Japanese source material than we were. Bravo Zulu. An example: for years American historians have portrayed the placement of Shoho in front of the Japanese invasion force as either 1) a bait force to lure the Americans away from Japan's main carrier force, or 2) at the very least an indication of extreme Japanese hubris, by sticking a lone light carrier's neck out waaaay too far. It turns out that there were a number of Japanese staff officers that were appalled at the dangers Shoho was being exposed to, and lobbied for her inclusion in the main carrier force instead (which would have made a lot more sense, frankly, and was a detail I hadn't known before.) But those officers were overridden in the name of keeping at least some air cover near the invasion force. What this demonstrates is that even here, at the very beginning of the war, the Japanese were already over their skis in terms of the fragility of their air power. All in all, Piegzik's book is a very welcome contribution to the English literature on the Pacific War. He has also written what is (from all accounts) a fine series on the Indian Ocean raid that I need to pick up as well. I am really looking forward to his continued publications in the field.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
C
Verified Purchase
Chorzepa
Omaha, US
★★★★★ 5
An excellent book
Format: Hardcover
An excellent book, based on Japanese documents—offering, for the first time, such a detailed account of the first aircraft carrier battle, presented from the Japanese perspective. It covers every Japanese aircraft involved, as well as the fates of their naval aircrews. A must-read for anyone interested in World War II in the Pacific.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 8, 2026
J
Verified Purchase
james
Dallas, US
★★★★★ 5
Excellent book.
Format: Audiobook
History of WWII. Great research.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 21, 2026
L
Verified Purchase
LynneC
Draper, US
★★★★★ 4
Good Book, not Parshall though
Format: Kindle
The author uses more Japanese terms than any similar book that I've read but uses western naming conventions for Japanese people. I don't quite know what to think. Good diagrams.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 12, 2025
R
Verified Purchase
Robert K. B
Fort Morgan, US
★★★★★ 5
Japanese mindset Coral Sea
Format: Kindle
This book gave me fresh insights to the Battle of the Coral Sea. I feel like I have an idea as to what was going through the Japanese minds. Well written. He make it easy to follow each step of the battle.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 19, 2026

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