SKU: 48823085822

GRP75 Rabbit Polyclonal Antibody

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Description

GRP75 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen GRP75 Synonyms Stress 70 protein, mitochondrial; 75 kDa glucose regulated protein (GRP 75); Heat shock 70 kDa protein 9; Heat shock protein family A member 9; Mortalin (MOT); Peptide binding protein 74 (PBP74); HSPA9B; mt HSP70; HSPA9 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Mitochondrion, Endoplasmic reticulum Accession P38646 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC

Product Specification


Host Rabbit
Antigen GRP75
Synonyms Stress-70 protein, mitochondrial; 75 kDa glucose-regulated protein (GRP-75); Heat shock 70 kDa protein 9; Heat shock protein family A member 9; Mortalin (MOT); Peptide-binding protein 74 (PBP74); HSPA9B; mt-HSP70; HSPA9
Immunogen Recombinant Protein
Location Cytoplasm, Nucleus, Mitochondrion, Endoplasmic reticulum
Accession P38646
Antibody Type Polyclonal antibody
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt, Mk
Positive Sample MCF7, HeLa, PANC-1, Jurkat, K562, NIH/3T3, mouse liver, PC-12, rat brain, COS-7
Purification Immunogen Affinity
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt, Mk
IHC-P 1:200 Hu, Ms, Rt
ICC 1:500 Hu

Background

GRP75, also known as mortalin or HSPA9, is an evolutionarily highly-conserved 75-kDa heat-shock protein that resides mainly in mitochondria but also shuttles to cytosol, ER, plasma membrane and even nucleus; it functions as a multifunctional molecular chaperone that binds unfolded or misfolded proteins in an ATP-dependent manner to prevent aggregation, drives import and proper folding of nascent mitochondrial precursors, participates in mitochondrial biogenesis, iron–sulfur cluster assembly, calcium homeostasis, and quality-control proteolysis, and additionally regulates stress response, cell-cycle progression, senescence and apoptosis by modulating p53, telomerase and other signaling pathways; consequently, its overexpression is frequently observed in many tumors where it promotes survival and chemoresistance, whereas its loss-of-function mutations cause severe neurodegenerative and mitochondrial disorders, making GRP75 a pivotal hub linking bioenergetics, proteostasis and human disease.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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SKU: 48823085822

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4.8 ★★★★★
Based on 16 reviews
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Product Reviews
R
Verified Purchase
Room112
Charlottesville, US
★★★★★ 5
Great for big dogs
Size: Medium, Number of Items: 1
Our pup is now 15 months old (nearly 110 lb and still growing). We got this ball when he was 3 or 4 months old. GOODS - - Our pup fetches with extreme drive, and the rope helps him quickly snatch the ball off the ground (versus a tennis ball, in which we are worried he will go head over heels at times) - Our pup also loves to play fetch in the water, and this ball floats great and again, the rope gives another point to bite onto - The yellow color is easy to see, even in grass - Our pup typically fetches the ball, and leaves the rope mostly out of his mouth. So, throwing the ball doesn't result in saliva-covered hands - It's pretty easy to throw the ball 50', and possible to throw it 100' - It doesn't roll/bounce, so if you are for example playing fetch on your front lawn and are concerned with a tennis ball rolling into the street, this one alleviates that issue - Our pup is spoiled and has several balls. This is absolutely his go to ball. We have woken up in the morning before to see him standing next to the bed with the ball in his mouth, asking us to get up and play. BADS - - Occasionally when he goes to fetch it, he will step on the rope as he tries to pull up on the ball. - We have gotten this ball stuck in trees multiple times. In fact, there is one stuck on the roof of our church from playing fetch on the lawn there. :-/ Not a fault of the ball, but if you start whipping it around like nunchucks, it might not go where you want. - The near max you can through this ball is 100'. And since it doesn't roll/bounce, throw distance is throttled. We often play fetch in a local baseball field, and have no issue wearing him out with this ball. However, if you are planning on throwing a ball the distance of half a football field, you might want to consider something else. SIZE - - We purchased both the medium and the large. Even though our pup is huge and can fit a soccer ball in his mouth, he still prefers the medium. It's easier for him to get in his mouth and breath while running back. The medium is the size of an orange, whereas the large is the size of a grapefruit. DURABILITY - - We have gone through about 4 of these balls, BUT this is because we lost 3 of them. We believe he dropped one out of the car window while we were driving, one is on the roof of our church, and I forget about the other one. On the first one we had, the stitching behind the black tape was down to a few threads after about 5 months. Given duration we use these balls (every day) and the joy he gets from them, I feel the durability is good for the price. - We do play tug with the ball at times, and no issues there Enjoy!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 17, 2013
G
Verified Purchase
Greg
Battle Creek, US
★★★★★ 3
Good but better options out there.
Good ball, but is a cheaper version of the Foamster sold online. The rope is cheap and comes apart, and can be abrasive to a dogs mouth. The Foamster uses a higher quality ball and are more durable and use grippy biothane straps rather than cheap rope. They are also made to order in the USA with lots of fun colors. Worth the extra money if your dog likes these balls.
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Reviewed in the United States on February 10, 2025
K
Verified Purchase
Kristen
Los Angeles, US
★★★★★ 5
Fun toy for fetch
Size: Medium, Number of Items: 1
Daisy loves this toy. I found it from her dog trainer, and it makes rewarding her with a quick tug of war and fetch really easy. Also it’s shockingly durable. It looks like foam, but she has not destroyed this one.
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Reviewed in the United States on November 11, 2025
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Verified Purchase
Dave
Charlottesville, US
★★★★★ 5
One Tough Ball!
Color: Blue
Our dogs are loving this ball. Our 1 yr old hound is a world-class chewer and he can't make a dent in this ball. The interactive buzzing and bouncing keeps them entertained for long durations. It's a mite noisy but the barking from the 1 yr old is much louder, lol. Even turned off, they like playing with it and chewing on it. Based on the tough construction, we think it will last much longer than traditional chew balls.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 22, 2026
J
Verified Purchase
Janice A
Grantham, US
★★★★★ 5
My puppy’s favorite
Color: Orange
Great quality and built to last. My dog really enjoys playing with it and stays entertained for quite a while. The material is strong yet safe, and the included drawstring bag is a convenient extra for easy storage. Is colorful and my become my puppy’s favorite.
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Reviewed in the United States on March 1, 2026

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