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Description
SDF-1α/CXCL12 Protein, MouseProduct Specification Species Mouse Synonyms Stromal cell derived factor; SDF 1; 12 O tetradecanoylphorbol 13 acetate repressed protein 1 (TPAR1); C X C motif chemokine 12; Pre B cell growth stimulating factor (PBSF); Thymic lymphoma cell stimulating factor (TLSF) Accession P40224 Amino Acid Sequence Lys22 Lys89 Expression System E. coli Molecular Weight 8 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated
Product Specification
| Species | Mouse |
| Synonyms | Stromal cell-derived factor; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 (TPAR1); C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor (PBSF); Thymic lymphoma cell-stimulating factor (TLSF) |
| Accession | P40224 |
| Amino Acid Sequence | Lys22-Lys89 |
| Expression System | E.coli |
| Molecular Weight | 8 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 300mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | J Mol Med (Berl). 2014 May; 92(5):433-9. |
Background
SDF-1α, also known as CXCL12, is a chemokine protein that plays a critical role in immune cell trafficking, hematopoiesis, and tissue repair. It is produced by stromal cells, endothelial cells, and other cell types in response to various stimuli, including inflammation and tissue injury. SDF-1α/CXCL12 exerts its biological effects by binding to its receptor CXCR4, a G protein-coupled receptor expressed on the surface of immune cells, hematopoietic stem cells, and other cell types.
The protein structure of SDF-1α/CXCL12 consists of a conserved N-terminal region and a flexible loop region, which is important for receptor binding and activation of downstream signaling pathways. The interaction between SDF-1α/CXCL12 and CXCR4 regulates the migration, homing, and retention of immune cells in specific tissues, as well as the mobilization and homing of hematopoietic stem cells.
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