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Description
Mouse Anti-Human CD140a Antibody (S-2840)Product Specification Host Mouse Antigen CD140a Synonyms Platelet derived growth factor receptor alpha; PDGF R alpha; PDGFR alpha; Alpha platelet derived growth factor receptor; Alpha type platelet derived growth factor receptor; CD140 antigen like family member A; CD140a antigen; Platelet derived growth factor alpha receptor; Platelet derived growth factor receptor 2 (PDGFR 2); PDGFR2; RHEPDGFRA; PDGFRA Location Cell membrane Accession P16234 Clone
Product Specification
| Host | Mouse |
| Antigen | CD140a |
| Synonyms | Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2 (PDGFR-2); PDGFR2; RHEPDGFRA; PDGFRA |
| Location | Cell membrane |
| Accession | P16234 |
| Clone Number | S-2840 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | A204 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD140a (also called platelet-derived growth factor receptor-alpha, PDGFR-α) is a 170-kDa glycosylated cell-surface receptor tyrosine kinase encoded by the PDGFRA gene, featuring an extracellular ligand-binding region with five immunoglobulin-like domains, a single transmembrane segment and an intracellular split tyrosine-kinase domain; upon binding PDGF-AA, -AB or -BB it forms homo- or heterodimers, triggers downstream signalling cascades that drive proliferation, migration and differentiation of mesenchymal and glial cells, and is indispensable for embryogenesis of kidney, testis and other organs, wound healing and maintenance of hematologic tissues, while PDGFRA mutations or amplifications are linked to clonal hypereosinophilic neoplasms, gastrointestinal stromal tumours, gliomas and hepatocellular carcinoma, making CD140a a potential therapeutic target in these cancers .
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Exchange/Return Notes
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