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Description
Human CCL26/Eotaxin-3 (Culture media & Plasma) OneStep ELISA KitProduct Specification Antigen CCL26 Eotaxin 3 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 3. 1% Inter assay: 4. 2% Sample type Cell culture supernatant; Plasma Assay type Sandwich (quantitative) Sensitivity 0. 568 pg mL Range 4. 69 pg mL 300 pg mL Recovery Cell culture supernatant: 96%
Product Specification
| Antigen | CCL26/Eotaxin-3 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 3.1%； Inter-assay: 4.2% |
| Sample type | Cell culture supernatant; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.568 pg/mL |
| Range | 4.69 pg/mL – 300 pg/mL |
| Recovery | Cell culture supernatant: 96% Plasma: 119% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Human CCL26, also known as Eotaxin-3, is a ~8 kDa CC chemokine encoded by the SCYA26 gene on chromosome 7q11.23. It is primarily produced by cytokine-stimulated endothelial cells and, to a lesser extent, by fibroblasts and bronchial epithelial cells. CCL26 exerts its biological effects by binding and signaling predominantly through the chemokine receptor CCR3, a receptor highly expressed on eosinophils, basophils, and a subset of T-helper 2 (Th2) lymphocytes. Consequently, its principal function is the selective recruitment and activation of these leukocytes, positioning it as a critical mediator in the pathogenesis of allergic inflammation. CCL26 is notably upregulated in various atopic diseases, such as asthma, atopic dermatitis, and allergic rhinitis, and its expression is strongly induced by the key Th2 cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). Due to its specific receptor interaction and induction profile, CCL26 is considered a significant biomarker and a potential therapeutic target for modulating eosinophil-driven inflammatory responses.
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