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Description
PI3 Kinase p110α Recombinant Rabbit mAb (S-3130)Product Specification Host Rabbit Antigen PI3 Kinase p110 Synonyms Phosphatidylinositol 4,5 bisphosphate 3 kinase catalytic subunit alpha isoform; PI3 kinase subunit alpha; PI3K alpha; PI3Kalpha; PtdIns 3 kinase subunit alpha; Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha (PtdIns 3 kinase subunit p110 alpha; p110alpha); Phosphoinositide 3 kinase alpha; Phosphoinositide 3 kinase catalytic alpha polypeptide; Serine
Product Specification
| Host | Rabbit |
| Antigen | PI3 Kinase p110α |
| Synonyms | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha (PtdIns-3-kinase subunit p110-alpha; p110alpha); Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PIK3CA |
| Location | Cytoplasm |
| Accession | P42336 |
| Clone Number | S-3130 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NIH/3T3, C2C12, mouse brain |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
PI3 Kinase p110α (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) is a 1,068-amino-acid lipid kinase that, in complex with its regulatory subunit p85, phosphorylates PIP₂ to generate the second messenger PIP₃, thereby activating the PI3K/AKT/mTOR pathway that controls cell growth, survival, metabolism, and angiogenesis; encoded by PIK3CA, it contains an N-terminal adaptor-binding domain, a Ras-binding domain, a C2 domain, a helical domain, and a C-terminal kinase domain, and is the most frequently mutated oncogene in human cancers, with hotspot mutations (e.g., E545K and H1047R) causing constitutive lipid kinase activity and driving tumorigenesis.
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