SKU: 51738867811

Biotinylated SIRP-α/CD172A Fc&Avi Tag Protein, Mouse

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Description

Biotinylated SIRP-α/CD172A Fc&Avi Tag Protein, MouseProduct Specification Species Mouse Synonyms BIT, MFR, MYD1, P84, PTPNS1,SHP substrate 1, SHPS1, SHPS1, CD172A Accession P97797 1 Amino Acid Sequence Lys32 Asn373, with C hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 95 110kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Mouse
Synonyms BIT, MFR, MYD1, P84, PTPNS1,SHP substrate 1, SHPS1, SHPS1, CD172A
Accession P97797-1
Amino Acid Sequence Lys32-Asn373, with C-hIgG1 Fc and Avitag
Expression System HEK293
Molecular Weight 95-110kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Barclay, A.N. & M.H. Brown (2006) Nat. Rev. Immunol. 6:457. 2. vanBeek, E.M. et al. (2005) J. Immunol. 175:7781. 3. Liu, Y. et al. (2005) J. Biol. Chem. 280:36132. 4. Kharitonenkov, A. et al. (1997) Nature 386:181.

Background

Signal regulatory protein alpha (SIRP alpha, designated CD172a), also called SHPS-1 (SHP substrate 1) and previously, MyD-1 (Myeloid/Dendritic-1), is a monomeric ~90 kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPs are paired receptors, with similar extracellular domains but differing C-termini and functions. The 503 amino acid (aa) human SIRP alpha contains a 342 aa extracellular domain (ECD), with one V-type, and two C1 type Ig domains, and three potential N glycosylation sites. It has a 110 aa cytoplasmic sequence with ITIM motifs that recruit tyrosine phosphatases SHP-1 and SHP-2 when phosphorylated.SIRP alpha is expressed mainly on myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It is also found on neurons, smooth muscle and endothelial cells. SIRP alpha shows adhesion to the ubiquitous CD47/IAP (integrin associated protein), while SIRP gamma binds more weakly and SIRP alpha 1 does not bind at all.Mouse and human SIRP alpha -CD47 binding only cross-reacts for specific polymorphisms and influences engraftment of xenotransplanted stem cells. SIRP alpha engagement generally produces a negative regulatory signal. Low SIRP alpha recognition of CD47, which occurs on aged erythrocytes or platelets or xenogenic cells, promotes clearance of CD47low cells from circulation. SIRP alpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.

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SKU: 51738867811

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4.3 ★★★★★
Based on 24 reviews
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Product Reviews
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Verified Purchase
Jacki Torres
Fort Morgan, US
★★★★★ 4
Functional and Good Quality
Color: 01-silver, Color: 01-silver
I give this SMARTAKE paper towel holder 4 stars. Overall, it's a very good product that I would recommend, but it has one minor drawback that takes away a star. The Positives Quality and Stability: The holder feels good quality, and the material (steel) is sturdy. Once placed on the counter, it's stable and adheres well to the surface. Assembly and Use: It was easy to put together; just read the instruction manual. I confirm that it works well even with large paper towel rolls. Furthermore, it's not difficult to change the roll at all. The Drawback The only problem is the small mechanism that's supposed to adjust and hold the roll (the piece that prevents it from twisting too much). As the paper gets used up, this piece doesn't do its job properly, and the paper unwinds more than it should. Conclusion: If you're looking for a modern, stable, and well-made holder for your kitchen, this is excellent. Just keep in mind that the adjuster isn't the best, but other than that, it does its job perfectly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 18, 2025
P
Verified Purchase
Patty C
Fort Morgan, US
★★★★★ 5
Durable and nice look
Color: 02-black
Nice quality and nice look for our kitchen
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Reviewed in the United States on May 30, 2026
K
Verified Purchase
K. K.
Battle Creek, US
★★★★★ 5
Classic holder keeps paper towels in place in a breeze.
Color: 06-bronze
This classic paper towel holder works perfectly. I had constantly unrolling paper towels in the breeze. This holder keeps everything in place now. So nice. Plus, it has a sleek, uncluttered design. I’m very pleased.
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Reviewed in the United States on May 18, 2026
T
Verified Purchase
Terry Anne
Omaha, US
★★★★★ 3
Only holds towels in place when it is full or 1/2 full
Color: 01-silver
If you are buying this for the feature of holding the paper towels in place so you can just rip one, I think you will be disappointed. Once the roll becomes smaller (and I tried changing the arm) the arm does not touch the towels. I do like the firm grip on the counter. My other dissatisfaction is the base gets water spots. Being near the sink this happens frequently. It does its job and is attractive.
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Reviewed in the United States on May 21, 2026
J
Verified Purchase
Jay
New York, US
★★★★★ 5
Stylish
Color: 01-silver
Good sturdy stand for paper towels. Has small suction cups on bottom for stability. Good finish and good fit under the counter. Heavy base and not flimsy feeling. Brushed aluminum matched other appliances well.
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Reviewed in the United States on January 6, 2026

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