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Description
MICA/MICB Recombinant Rabbit mAb (S-1589-10)Product Specification Host Rabbit Antigen MICA MICB Synonyms MHC class I polypeptide related sequence A; MIC A; PERB11. 1; Immunogen Recombinant Protein Location Cytoplasm, Cell membrane, Endoplasmic reticulum Accession Q29983 Q29980 Clone Number S 1589 10 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HCT 116, HeLa, A431, MCF7, HUVEC Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | MICA/MICB |
| Synonyms | MHC class I polypeptide-related sequence A; MIC-A; PERB11.1; |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Cell membrane, Endoplasmic reticulum |
| Accession | Q29983、 Q29980 |
| Clone Number | S-1589-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HCT 116, HeLa, A431, MCF7, HUVEC |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
MICA (MHC class I polypeptide-related sequence A) and MICB (MHC class I polypeptide-related sequence B) are stress-inducible proteins that belong to the MHC class I family but do not bind to β2-microglobulin or present peptides. They are encoded by genes located within the HLA class I region of chromosome 6. MICA and MICB are expressed on the cell membrane in response to cellular stress or cancer transformation. These proteins act as ligands for the NKG2D receptor, which is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells. The binding of MICA/B to NKG2D can activate these immune cells, leading to cytotoxic responses against stressed or transformed cells. MICA and MICB are highly polymorphic, with over 106 alleles reported for MICA and 25 for MICB. This polymorphism may affect their affinity for NKG2D and, consequently, the activation thresholds of NK and T cells.
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