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Description
GP120 (group M/subtype B/Isolate MN) His Tag, HIV-1Product Specification Species HIV Antigen GP120 Synonyms GP120, GP120 CN54 Accession P05877 Amino Acid Sequence Lys32 Arg513, with C terminal 6* His
Product Specification
| Species | HIV |
| Antigen | GP120 |
| Synonyms | GP120, GP120-CN54 |
| Accession | P05877 |
| Amino Acid Sequence |
Lys32-Arg513, with C-terminal 6* His KLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATQACVPTDPNPQEVELVNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNTTNTNNSTANNNSNSEGTIKGGEMKNCSFNITTSIRDKMQKEYALLYKLDIVSIDNDSTSYRLISCNTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKKFSGKGSCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTDNAKTIIVHLNESVQINCTRPNYNKRKRIHIGPGRAFYTTKNIIGTIRQAHCNISRAKWNDTLRQIVSKLKEQFKNKTIVFNQSSGGDPEIVMHSFNCGGEFFYCNTSPLFNSTWNGNNTWNNTTGSNNNITLQCKIKQIINMWQEVGKAMYAPPIEGQIRCSSNITGLLLTRDGGKDTDTNDTEIFRPGGGDMRDNWRSELYKYKVVTIEPLGVAPTKAKRRVVQREKRGGGSHHHHHH
|
| Expression System | HEK293 |
| Molecular Weight | 95-118kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles. |
| Reference |
2.Pöhlmann, S.; Baribaud, F.; Lee, B.; Leslie, G.J.; Sánchez, M.D.; Hiebenthal-Millow, K.; Münch,J.;Kirchhoff,F.;Doms,R.W.DC-SIGN.Interactions with Human Immunodeficiency Virus Type 1 and 2 and SimianImmunodeficiency VirusJ. Virol.,2001,75, 4664-4672.(b) Cunningham, A.L.;Harman,A.N.;Donaghy H.DC-SIGN 'AIDS' HIV immune evasion and infection.Nat. Immunol.,2007, 8, 556-558. 3.A Flores , E Quesada.Entry inhibitors directedtowards glycoprotein gp120: an overview on a promising target for HIV-1therapy.Curr Med Chem. 2013 Feb 1;20(6):751-71. |
Background
Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. The glycoprotein gp120 forms a globular structure, consisting of 25 β strands, five α helices and ten loops. Each envelope glycoprotein complex is formed by a heterodimer resulting from the non-covalent association of two proteins called gp41 and gp120. Glycoprotein gp41 adopts a transmembrane location, anchored to the viral membrane and behaving as physical support of gp120, the latter being fully located on the external surface of the HIV-1 membrane. Both gp41 and gp120 are homotrimeric proteins synthesized from a common single chain polypeptide precursor gp160, which eventually is cleaved post-transductionally yielding the mature independent envproteins. The gp120 glycans have been suggested to play an important role in viral transmission through interaction with endogenous lectins able to selectively recognize specific glycan motifs in HIV-1, such as the C-type lectin DC-SIGN, which is found on the surfaces of dendritic cells and is thought to aid in the transport of the virus to anatomical sites rich in CD4+T cells. Moreover, these oligosaccharides are crucial in avoiding an efficient neutralizing antibody response against HIV-1 in infected people.
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