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Description
IL-2 Rγ/CD132 His Tag Protein, HumanProduct Specification Species Human Synonyms IL2RG,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC Accession P31785 1 Amino Acid Sequence Leu23 Asn254 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 50 70kDa (Reducing) Purity 95% by SDS PAGE & > 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | IL2RG,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC |
| Accession | P31785-1 |
| Amino Acid Sequence | Leu23-Asn254 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Sugamura K, Asao H, Kondo M, et al. The interleukin-2 receptor γ chain: its role in multiple cytokine receptor complexes and T-cell development in XSCID. Annu Rev Immunol. 1996;14:179-205. |
Background
IL-2 receptor gamma chain (IL-2 Rγ, CD132) is the 64 kDa shared signaling subunit of the hematopoietin receptor family that converts low-affinity IL-2 binding into a high-affinity, signal-competent complex. Independently, CD132 does not bind IL-2, yet its cytoplasmic tail is obligatory for recruitment of Janus kinase 3 (JAK3) and subsequent activation of STAT5, PI3K and MAPK cascades that drive T-, B- and NK-cell survival, proliferation and differentiation. The same γ-chain is also exploited by IL-4, IL-7, IL-9, IL-15 and IL-21 receptors, explaining why germ-line mutations in IL2RG produce X-linked severe combined immunodeficiency.
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